Aimiliani Konstantinou

The paper maps over 20,000 human protein-protein interactions mediated by short linear motifs using a peptide library screening approach.

The paper systematically identifies SLiM-binding interactions of USP family auxiliary domains using proteomic and biochemical methods, revealing functional redundancy and motif specificity.

This study uses phage-based deep mutational scanning to identify binding determinants of short linear motifs between human and SARS-CoV-2 proteins, refining motifs and identifying affinity-enhancing mutations.