Filip Mihalič

The paper maps over 20,000 human protein-protein interactions mediated by short linear motifs using a peptide library screening approach.

The paper demonstrates that sulanemadlin, a stapled peptide inhibitor of MDM2, specifically activates p53 in zebrafish without inducing apoptosis, enabling direct in vivo studies of p53 regulation.

This study uses phage-based deep mutational scanning to identify binding determinants of short linear motifs between human and SARS-CoV-2 proteins, refining motifs and identifying affinity-enhancing mutations.

This study traces the evolutionary origins and molecular changes of a chikungunya virus outbreak in Thailand, identifying mutations linked to increased virulence and transmission.

The paper investigates the evolution of p53/MDM2 interaction in teleosts, finding that affinity is conserved through compensatory changes in both conserved and non-conserved regions.

The paper identifies SARS-CoV-2 protein domains that interact with human peptides and discovers antiviral peptides targeting Nsp9 and Nsp16.

The paper examines the evolution of p53/MDM2 interaction affinity across species, finding significant variation in binding strength and suggesting plasticity in motif-mediated interactions.