Caroline Benz

An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions

The paper maps over 20,000 human protein-protein interactions mediated by short linear motifs using a peptide library screening approach.

High-throughput discovery and deep characterization of cyclin-CDK docking motifs

The paper identifies and characterizes cyclin-CDK docking motifs through high-throughput peptide binding assays and structural analysis, revealing a broader repertoire of motif types and binding mechanisms.

Defining short linear motif binding determinants by phage-based multiplexed deep mutational scanning

This study uses phage-based deep mutational scanning to identify binding determinants of short linear motifs between human and SARS-CoV-2 proteins, refining motifs and identifying affinity-enhancing mutations.

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

The paper identifies SARS-CoV-2 protein domains that interact with human peptides and discovers antiviral peptides targeting Nsp9 and Nsp16.

Use of viral motif mimicry improves the proteome-wide discovery of human linear motifs

The paper identifies human linear motifs by analyzing viral protein interactions, finding 8,400 motif instances with 105 supported by multiple filters.