Author

João Lança

Instituto de Tecnologia Química e Biológica António XavierORCID 0009-0009-7706-7792Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Raquel Sá‐LeãoiD· 3 shared Catarina CandeiasiD· 2 shared Joana Bryton· 2 shared João BorralhoiD· 2 shared Wilson AntunesiD· 2 shared Amir PandiiD· 1 shared Carina ValenteiD· 1 shared Daniela BrásiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

Raquel Sá‐LeãoORCID

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3 papers

Recent·Most cited

MicrobiologymBioPeer-reviewedOct 12, 2026

Serotype-independent inhibition of S. pneumoniae by SMiTE, a commensal-derived bacteriocin

João Lança, Joana Bryton, João Borralho…·Raquel Sá‐Leão

The paper identifies SMiTE, a commensal-derived bacteriocin that effectively inhibits multiple Streptococcus pneumoniae serotypes without harming commensals.

DOI 10.1128/mbio.01703-26

mouseproteomics

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MicrobiologymBioPeer-reviewedMar 3, 2026

Streptococcus mitis bacteriocins drive contact-dependent lysis of S. pneumoniae facilitating transformation in multispecies environments

João Borralho, João Lança, Joana Bryton…·Raquel Sá‐Leão

This study identifies bacteriocins in S. mitis that lyse S. pneumoniae, promoting DNA release and enhancing horizontal gene transfer in multispecies biofilms.

2 citations

humanproteomics

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MicrobiologybioRxivPreprintJun 6, 2025

Bacteriocin-mediated prevention of secondary pneumococcal pneumonia by a human commensal Streptococcus mitis strain

Catarina Candeias, João Lança, Marta Alenquer…·Raquel Sá‐Leão

This paper shows that a commensal Streptococcus mitis strain prevents secondary pneumococcal pneumonia by inhibiting pneumococcal colonization and dissemination through bacteriocins.

2 citations

mouseexperimental assay

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