Cancer BiologybioRxivPreprint
Fibroblasts drive differential response in immunotherapy via IL-6 in bioengineered 3D cancer constructs
Srija Chakraborty, Marco Rodriguez, Aleksander Skardal
This study investigates how fibroblasts influence immunotherapy efficacy in 3D cancer models, identifying IL-6 as a key mediator of tumor-fibroblast interactions that can be targeted to restore NK cell function.
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