Aleksander Skardal

Development of a Thyroid Cancer to Lung Metastasis-on-a-Chip Model

This paper develops a metastasis-on-a-chip model to study thyroid cancer to lung metastasis, showing that RCAN1.4 suppression enhances metastasis and that NK-92 cells reduce metastases.

Engineering a 3D Lung Co-culture Platform to Model Epithelial-Fibroblast Interactions in Pulmonary Fibrosis

This paper develops a 3D lung co-culture model to simulate epithelial-fibroblast interactions in IPF, showing it captures key fibrotic processes like myofibroblast differentiation and collagen disorganization.

Establishment of a patient-derived adrenocortical carcinoma 3D tumor construct platform for evaluation of therapeutic strategies

This paper develops patient-derived ACC tumor constructs to evaluate therapeutic strategies, showing they can test chemotherapies, targeted therapies, and immunotherapies.

Evaluation of natural killer cell tumor homing and effector function in response to CDK4/6 and AURKA inhibition in a melanoma tumor-on-a-chip platform

This study evaluates how CDK4/6 and AURKA inhibition enhances NK cell homing and tumor-killing in melanoma models using tumor-on-a-chip platforms.

Fibroblasts drive differential response in immunotherapy via IL-6 in bioengineered 3D cancer constructs

This study investigates how fibroblasts influence immunotherapy efficacy in 3D cancer models, identifying IL-6 as a key mediator of tumor-fibroblast interactions that can be targeted to restore NK cell function.