Allele-specific expression reveals interactions between genetic variation and environment

Introduction Introduction Main text Methods References The impact of environment on human health is dramatic, with major risk factors including substance use1, diet2 and exercise3. However, identifying interactions between the environment and an individuals genetic background (GxE) has been hampered by statistical and computational challenges4,5. By combining RNA sequencing of whole blood and extensive environmental annotations collected from 922 individuals6, we have evaluated GxE interactions at a cellular level. We have developed EAGLE, a hierarchical Bayesian model for identifying GxE interactions based on association between environment and allele-specific expression (ASE). EAGLE inc ...