Amanda J. Lea

The paper examines gene expression evolution in primate immune cells under different conditions, finding that perturbation-responsive genes evolve faster than baseline genes.

This study examines how APOE isoforms affect biological outcomes in industrialized and non-industrial environments, finding lifestyle-dependent effects and weak reproductive benefits for APOE ε4.

This study evaluates how face-to-BMI Vision Transformer models perform across diverse human populations, finding that training on population-specific data improves accuracy, while global training data enhances performance in underrepresented groups.

This study examines how lifestyle changes in Indigenous Orang Asli communities in Malaysia affect sleep patterns and circadian rhythms, finding delayed timing and shorter duration with improved quality.

The paper examines how early-life and current environments affect immune function in the Orang Asli, finding current lifestyle has stronger effects on immune gene expression than early-life conditions.

The paper develops and evaluates tailored illustrations to improve community understanding of genetics concepts through iterative feedback and analysis of engagement patterns.

The paper shows that age and early life adversity affect DNA methylation across tissues in macaques, with distinct but overlapping patterns.

This paper shows that rhodopsin's light protection mechanism evolved to sequester toxic retinal and protect retinal cells, with implications for human disease.

The paper examines how early life environments affect adult cardiometabolic health in the Orang Asli, finding support for developmental constraints over predictive adaptive responses.

This study shows that early life adversity in rhesus macaques affects growth, reproductive timing, and lifetime reproductive success, with adversity intensifying trade-offs between growth and reproduction.

The paper identifies methylation-dependent genetic effects on regulatory elements in diverse human genomes using a multiplexed mSTARR-seq assay, revealing 8,020 sites with genetic effects, 42.3% of which vary with methylation state.

This study tests developmental constraints and adaptive response hypotheses for early life effects on fertility in wild baboons but finds no strong support for these explanations.

The paper optimizes a reduced representation DNA methylation sequencing protocol for cost-effective, population-scale studies across species.

The paper analyzes RNA-seq data from public databases and finds significant underrepresentation of non-European populations, highlighting biases in population descriptors.

This study identifies DNA methylation signatures in wild baboons linked to early life adversity, showing exposure-dependent effects and functional relevance of methylation changes.

This study examines sex differences in immune function and disease risk across populations, finding no consistent support for the evolutionary mismatch hypothesis.

The paper identifies differential gene regulation across human ancestries by analyzing chromatin activity and finds enhancers show stronger selection signals than promoters.

The paper analyzes gene expression variance across 57 RNA-seq datasets to show that transcriptional variance is consistent across tissues and linked to gene function, sequence variation, and regulatory features.

The paper uses mSTARR-seq to show DNA methylation interacts with environmental factors like IFNA and influenza virus in human macrophages, but not for early life adversity sites.

The paper maps genetic effects on gene expression across diverse environmental conditions and finds context-dependent eQTLs enriched for disease-associated loci.

This study identifies gene regulatory differences linked to dominance rank and social bond strength in wild baboons, showing sex-specific effects and distinct immune responses to social factors.

This study examines how Western and Mediterranean diets affect monocyte gene expression and social behavior in macaques, finding proinflammatory gene changes and behavioral differences.

This study finds that high-ranking male baboons show accelerated epigenetic aging, suggesting a trade-off between reproductive success and lifespan.

This study identifies genetic and environmental factors that disrupt trait correlations, showing environmental perturbations reduce correlations and genetic factors influence correlation patterns.

The paper evaluates factors affecting differential methylation detection in bisulfite sequencing data and provides tools for power analysis.

The paper develops mSTARR-seq to quantify DNA methylation effects on regulatory elements, identifies MD regulatory elements, and predicts methylation-gene expression correlations.