bioRxivImmunologyPreprint
SARS-CoV-2 BA.4 infection triggers more cross-reactive neutralizing antibodies than BA.1
S. Richardson, T. Motlou, M. van der Mescht, B. Lambson, J. Everatt, D. Amoako, A. Van Gottberg, N. Wolter, Z. de Beer, T. Roma de Villiers, A. Bodenstein, G. van den Berg, T. M. Rossouw, M. Boswell, V. Ueckermann, J. Bhiman, P. Moore
Abstract
SARS-CoV-2 variants of concern (VOCs) differentially trigger neutralizing antibodies with variable cross-neutralizing capacity. Here we show that unlike SARS-CoV-2 Omicron BA.1, which triggered neutralizing antibodies with limited cross-reactivity, BA.4/5 infection triggers highly cross-reactive neutralizing antibodies. Cross-reactivity was observed both in the absence of prior vaccination and also in breakthrough infections following vaccination. This suggests that next-generation vaccines incorporating BA.4, which is spreading globally, might result in enhanced neutralization breadth.
- organism: human
- assay: proteomics
- research focus: host-pathogen & immune response
- approach: experimental assay
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Distinct antigenic properties of the SARS-CoV-2 Omicron lineages BA.4 and BA.5
B. J. Willett, A. Kurshan, … T. P. Peacock·bioRxiv·May 25, 2022
- Exposure to BA.4/BA.5 Spike glycoprotein drives pan-Omicron neutralization in vaccine-experienced humans and mice
- Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5
- Neutralisation of SARS-CoV-2 Omicron subvariants BA.2.86 and EG.5.1 by antibodies induced by earlier infection or vaccination
R. Lassauniere, C. Polacek, … M. Rasmussen·bioRxiv·Oct 1, 2023
- SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies
S. M. Reincke, M. Yuan, … J. Kreye·bioRxiv·Sep 30, 2021
- Vaccine-breakthrough infection by the SARS-CoV-2 Omicron variant elicits broadly cross-reactive immune responses
R. Zhou, K. K.-W. To, … Z. Chen·bioRxiv·Dec 27, 2021