Author

K. K.-W. To

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 10 Approach:experimental assay· 9 Organism:human· 5 Organism:mouse· 5 Assay:proteomics· 5 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:flow cytometry· 2

Frequent Co-Authors

K.-Y. Yuen· 9 shared H. Chen· 6 shared H. Chu· 6 shared J. F.-W. Chan· 5 shared J.-P. Cai· 4 shared K.-H. Chan· 4 shared K.-K. Au· 4 shared P. Wang· 4 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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9 shared papersMicrobiology

K.-Y. Yuen

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron-BA.2

R. Zhou, N. Liu, X. Li, Q. Peng, C.-K. Yiu, H. Huang, D. Yang, Z. Du, H.-Y. Kwok, K.-K. Au, J.-P. Cai, I. F.-N. Hung, K. K.-W. To, X. Xu, K.-Y. Yuen, Z. Chen

This study evaluates the effectiveness of three-dose SARS-CoV-2 vaccination against Omicron BA.2 breakthrough infections and finds that third-dose vaccination significantly reduces infection rates and severity.

bioRxiv · May 9, 2022 · PreprintImmunology

Computation of Antigenicity Predicts SARS-CoV-2 Vaccine Breakthrough Variants

Y.-f. Hu, J.-c. Hu, H.-R. Gong, A. Danchin, R. Sun, H. Chu, I. F.-N. Hung, K. Y. Yuen, K. K.-W. To, B.-Z. Zhang, T. Yau, J.-D. Huang

This paper develops a computational model to predict SARS-CoV-2 variant antigenicity from sequence data, showing high accuracy in predicting neutralisation titre decreases for known variants and Omicron.

bioRxiv · Jan 19, 2022Evolutionary Biology

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

S. Yuan, Z.-W. Ye, R. Liang, K. Tang, A. J. Zhang, G. Lu, C. P. Ong, V. K.-M. Poon, C. C.-S. Chan, B. W. Y. Mok, Z. Qin, Y. Xie, H. Sun, J. O.-L. Tsang, T. T.-T. Yuen, , J. F. W. Chan

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

bioRxiv · Jan 12, 2022 · PreprintMicrobiology

An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge

B. Zhou, R. Zhou, J. F.-W. Chan, M. Luo, Q. Peng, S. Yuan, B. W.-Y. Mok, B. Chen, P. Wang, V. K.-M. Poon, H. Chu, C. C.-S. Chan, J. O.-L. Tsang, C. C.-Y. Chan, K.-K. Au, , Z. Chen

This study identifies a broadly neutralizing antibody, ZCB11, effective against SARS-CoV-2 Omicron and Delta variants, showing protection in hamsters.

bioRxiv · Jan 5, 2022 · PreprintImmunology

Vaccine-breakthrough infection by the SARS-CoV-2 Omicron variant elicits broadly cross-reactive immune responses

R. Zhou, K. K.-W. To, Q. Peng, J. M.-C. Chan, H. Huang, D. Yang, B. H.-S. Lam, V. W.-M. Chuang, J.-P. Cai, N. Liu, K.-K. Au, O. T.-Y. Tsang, K.-Y. Yuen, Z. Chen

This study examines immune responses in vaccine-breakthrough Omicron infections, finding rapid cross-reactive neutralizing antibodies and T cell responses against multiple variants.

bioRxiv · Dec 27, 2021Immunology

Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2

L. Liu, S. Iketani, Y. Guo, J. F.-W. Chan, M. Wang, L. Liu, Y. Luo, H. Chu, Y. Huang, M. S. Nair, J. Yu, K. K.-H. Chik, T. T.-T. Yuen, C. Yoon, K. K.-W. To, , D. D. Ho

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

bioRxiv · Dec 14, 2021Microbiology

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

B. Zhou, R. Zhou, J. F.-W. Chan, J. Zeng, Q. Zhang, S. Yuan, L. Liu, R. Robinot, S. Shan, J. Ge, H. Y.-H. Kwong, D. Zhou, H. Xu, C. C.-S. Chan, V. K.-M. Poon, , Z. Chen

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

bioRxiv · Oct 5, 2021 · PreprintMicrobiology

Low dose inocula of SARS-CoV-2 B.1.1.7 variant initiate more robust infections in the upper respiratory tract of hamsters than earlier D614G variants

B. W.-Y. Mok, H. Liu, S.-Y. Lau, S. D. Deng, S. Liu, R. C.-Y. Tam, T. T.-L. Ng, J. S.-L. Leung, P. Wang, K. K.-W. To, J. F.-W. Chan, K.-H. Chan, K.-Y. Yuen, G. K.-H. Siu, H. Chen

This study shows that the B.1.1.7 SARS-CoV-2 variant replicates and sheds more efficiently in hamsters' nasal cavities than earlier D614G variants with lower doses and shorter exposure.

bioRxiv · Apr 19, 2021 · PreprintMicrobiology

SARS-CoV-2 spike D614G variant exhibits highly efficient replication and transmission in hamsters

B. W. Y. Mok, C. J. Cremin, S.-Y. Lau, S. Deng, P. Chen, A. J. Zhang, A. C.-Y. Lee, H. Liu, S. Liu, T. T.-L. Ng, H.-Y. Lao, E. L.-K. Lee, K. S.-S. Leung, P. Wang, K. K.-W. To, , H. Chen

This study compares SARS-CoV-2 strains in hamsters, finding that the D614G spike variant shows higher replication and transmission efficiency.

bioRxiv · Aug 28, 2020 · PreprintMicrobiology

Pathogenicity, immunogenicity, and protective ability of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein

P. Wang, S.-Y. Lau, S. Deng, P. Chen, B. W.-Y. Mok, A. J. Zhang, A. C.-Y. Lee, K.-H. Chan, W. Song, K. K.-W. To, J. F.-W. Chen, K.-Y. Yuen, H. Chen

This study characterizes an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction, showing reduced pathogenicity and immunogenicity but strong protective immunity.

bioRxiv · Aug 24, 2020 · PreprintMicrobiology

Mapping the Immunodominance Landscape of SARS-CoV-2 Spike Protein for the Design of Vaccines against COVID-19

B.-z. Zhang, Y.-f. Hu, L.-l. Chen, Y.-g. Tong, J.-c. Hu, J.-p. Cai, K.-H. Chan, Y. Dou, J. Deng, H.-r. Gong, C. Kuwentrai, W. Li, X.-l. Wang, H. Chu, C.-h. Su, , J.-D. Huang

This study maps immunodominant sites on the SARS-CoV-2 spike protein using patient sera to identify potential vaccine candidates and demonstrates their neutralizing activity in mice.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology