Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA)
Cathal McCroryiD, Giovanni FioritoiD, Belinda HernándeziD, Silvia PolidoroiD, Aisling M O’HalloraniD, Ann M. Hever, Clíona Ní CheallaighiD, Ake Tzu-Hui LuiD, Steve HorvathiD, Paolo VineisiD, Rose Anne KennyiD
Abstract
The aging process is characterized by the presence of high interindividual variation between individuals of the same chronical age prompting a search for biomarkers that capture this heterogeneity. The present study examines the associations of four epigenetic clocks - Horvath, Hannum, PhenoAge, GrimAge - with a wide range of clinical phenotypes, and with all-cause mortality at up to 10-year follow-up in a sample of 490 participants in the Irish Longitudinal Study on Ageing. Results indicate that the GrimAge clock represents a step-improvement in the predictive utility of the epigenetic clocks for identifying age-related decline in an array of clinical phenotypes.
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