Ilja Demuth

The paper examines how polygenic indices for educational attainment change across birth cohorts and regions in Germany, finding stronger associations in recent cohorts and the East but weaker effects for women.

This study finds that DunedinPACE, an epigenetic clock, most consistently associates with cognitive decline in older adults compared to other DNAm clocks and telomere length.

This study shows that gut microbial metabolite imidazole propionate impairs endothelial function and promotes atherosclerosis in both human and animal models.

The paper examines immune cell profiles in individuals with genetic risk for ALS and AD, finding nominally significant associations but no significant associations after FDR correction.

The paper examines immune cell distributions in healthy individuals at high genetic risk of Parkinson's disease and finds no significant associations between polygenic risk scores and immune cell subtypes, though some nominally significant associations were observed.

The paper develops a multivariate methylation risk score using blood DNA methylation data to predict dementia risk and cognitive impairment in Alzheimer's and Parkinson's disease cohorts.

This paper conducts a GWAS to identify genetic loci associated with immune cell distributions in healthy individuals and links these to type 1 diabetes and long COVID risk.

The paper maps DNA methylation quantitative trait loci (meQTL) in three tissues and uses Mendelian randomization to link DNAm to Alzheimer's and Parkinson's disease risk.

The paper investigates the effects of short sleep on brain structure and cognitive function, finding that short sleepers without daytime tiredness have larger brain volumes but slightly lower cognitive scores.

The paper correlates DNA methylation patterns between buccal and brain samples to identify CpG sites with significant methylation correlations and genetic determinants.

This study examines the relationship between sleep duration and brain structure using MRI data, finding that 6.8 hours of sleep is associated with the most favorable brain outcomes, with genetic analyses suggesting homeostatic regulation of sleep duration.

The paper compares DNA methylation age estimates from a 7-CpG clock using MS-SNuPE and the MethylationEPIC array, finding high correlation and developing an adjustment formula for conversion between methods.

This study examines the relationship between epigenetic clocks, telomere length, and functional aging in older adults using cross-sectional and longitudinal data, finding no significant associations.

This study identifies 15 genetic loci associated with muscle weakness in older adults through a large meta-analysis, revealing new pathways linked to aging and health outcomes.

The paper examines the relationship between self-reported sleep parameters and cortical thinning in aging, finding associations with specific brain regions but not with memory decline or amyloid-β accumulation.

The paper examines how self-reported sleep relates to hippocampal atrophy across adulthood using data from the Lifebrain consortium and UK Biobank, finding that worse sleep is linked to faster hippocampal volume loss over time.

The paper analyzes genetic variants at the PCSK9 locus to assess their phenotypic effects on lipid levels and disease outcomes, finding concordance with PCSK9 inhibitor trials for myocardial infarction but discordance for type 2 diabetes.

The paper examines the relationship between dietary tyrosine intake, brain functional connectivity, and working memory performance in healthy elderly individuals, finding negative correlations between tyrosine intake and striatum-prefrontal cortex connectivity.