Giovanni Fiorito

This study shows that the FA recipient environment after HCT causes metabolic, redox, and epigenetic changes in donor-derived hematopoietic cells, even when donor chimerism is stable.

The paper benchmarks differential abundance analysis tools for human gut 16S rRNA data across configurations, showing that settings significantly impact performance and must be reported for interpretability.

This paper introduces a Deep Survival EWAS method to estimate risk profiles from pre-diagnostic DNA methylation data, showing improved identification of biologically relevant pathways in breast cancer.

This study identifies DNA methylation sites associated with coffee and tea consumption using EWAS, finding potential links to fatty liver disease through PHGDH expression.

The paper assesses sex-specific DNA methylation changes with aging using whole blood datasets, finding 43% of sex-associated probes show age-related methylation changes and higher methylation variability in males.

The paper assesses four epigenetic clocks' associations with health, cognition, and mortality in the TILDA cohort, finding GrimAge provides better predictive utility for age-related decline.

The paper analyzes genetic variants at the PCSK9 locus to assess their phenotypic effects on lipid levels and disease outcomes, finding concordance with PCSK9 inhibitor trials for myocardial infarction but discordance for type 2 diabetes.

This study investigates the association between CpG methylation and educational attainment, finding limited significant associations that may be influenced by confounding factors.