Ake Tzu-Hui Lu

DNA methylation clocks show heterochronic heart grafts shifting toward recipient age in syngeneic mice and 11 human recipients, while recipient mouse native heart, liver and blood show no consistent change.

This study develops epigenetic clocks for axolotls, revealing biphasic age prediction during early life but not later, and highlights methylome stability across lifespan.

This study shows that OSKM gene therapy in old rats improves spatial learning and memory, reduces epigenetic age, and reverses age-related DNA methylation changes in the hippocampus.

The paper introduces causality-enriched epigenetic clocks, DamAge and AdaptAge, to track detrimental and adaptive methylation changes linked to aging, showing their association with adverse outcomes and beneficial adaptations.

The paper develops universal epigenetic clocks that accurately estimate age across mammalian tissues using DNA methylation data from 185 species.

This study shows biological age can increase with stress and decrease with recovery, using epigenetic clocks in mice and humans.

The paper refines epigenetic predictors of chronological and biological age using large-scale EWAS and external validation, improving cAge prediction and outperforming existing bAge predictors.

The paper develops DNAmFitAge, a biological age indicator that integrates physical fitness metrics with epigenetic clocks to assess aging and health risks.

The paper investigates the association between sex steroid hormones and DNA methylation-based biomarkers of age and mortality risk in men and women, finding that higher testosterone and testosterone/estradiol ratio are linked to better epigenetic age and lower mortality risk in men.

The paper evaluates 41 DNA methylation predictors across 101 data preprocessing strategies, finding significant variation in performance and highlighting the importance of appropriate normalization for reliable results.

The paper develops DNA methylation clocks for clawed frogs, showing evolutionary conservation of epigenetic ageing mechanisms between frogs and mammals.

The paper develops a mammalian methylation array to profile methylation levels at conserved sequences across species, enabling cross-species comparisons and epigenetic biomarker development.

This paper develops epigenetic clocks for common marmosets using DNA methylation data and tests rapamycin's effect on epigenetic age, finding no significant impact.

This study develops an epigenetic clock for sheep and finds that castration slows aging and feminizes DNA methylation at androgen-regulated loci.

The paper identifies DNA repair hotspots in post-mitotic human neurons linked to genes essential for their identity and function.

This paper develops epigenetic clocks for dogs to estimate age and mortality risk, and identifies methylation sites linked to breed weight and lifespan.

This study uses DNA methylation profiles from bats to show that age and longevity are linked to specific methylation patterns, with longevity associated with immune and cancer-related genes.

This study develops pan-primate epigenetic clocks and sex predictors using DNA methylation data from 37 primate species, achieving high accuracy for age estimation across species.

This study identifies 137 genome-wide significant loci associated with DNA methylation biomarkers of ageing using DNAm and SNP data from over 41,000 individuals.

The paper assesses four epigenetic clocks' associations with health, cognition, and mortality in the TILDA cohort, finding GrimAge provides better predictive utility for age-related decline.

This paper conducts GWAS on two epigenetic age acceleration measures, identifying genetic variants and genes associated with each, and highlighting differences in their genetic architectures.

This study identifies genetic variants associated with epigenetic age acceleration and shows TERT's role in regulating the DNA methylation clock.