Constructing early diagnosis model of colorectal cancer based on expression profile

Abstract

purposeIn order to break through the restrictive factors such as the fecal occult blood test (FOBT) in the routine detection of bowel cancer, which is susceptible to diet and drugs, and the high cost and inconvenience of microscopy, Seeking a possible FOBT alternative. MethodsAn error back propagation neural network (BPNN) algorithm was used to construct a CRC diagnosis model based on expression profiles. ResultsThe accuracy of the model on the training and test sets is 0.943 and 0.935, respectively. AUC all reached above 0.95. ConclusionThe CRC molecular detection model based on expression profiles provides a possible alternative to FOBT. It provides a new approach and method for the clinical diagnosis of bowel cancer.