Q. Xiao

Structural insights into specific recognition of PTENα/β-NTE by WDR5 in cancer progression

The paper determines the crystal structure of PTEN-NTE bound to WDR5, revealing a specific binding motif that promotes tumor growth and suggests WDR5 inhibitors as potential cancer therapies.

Filter-aided expansion proteomics

The paper introduces FAXP, a method combining hydrogel expansion and mass spectrometry for high-resolution proteomics of FFPE tissues, showing improved resolution and efficiency over existing methods.

IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers

This study shows that adding intrinsically disordered regions (IDRs) to CARs improves their cytotoxicity against low-antigen cancers by enhancing signaling and killing activity.

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritis

This study identifies conserved myeloid subsets and disease-associated gene expression changes in kidney injury across lupus mouse models and human patients with lupus nephritis.

Chimeric Antigen Receptor Macrophages Target and Resorb Amyloid Plaques in a Mouse Model of Alzheimer's Disease

This paper demonstrates that CAR-Ms engineered to secrete M-CSF can target and reduce amyloid plaques in a mouse model of Alzheimer's disease.

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

Rigosertib promotes anti-tumor immunity via autophagic degradation of PD-L1 in colorectal cancer cells

Rigosertib promotes anti-tumor immunity by inducing autophagic degradation of PD-L1 in colorectal cancer cells, enhancing immune response and synergizing with checkpoint inhibitors.

An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

The paper identifies CCT020312, an mTOR-independent autophagy activator, which reduces tauopathy and prionopathy neurodegeneration phenotypes by enhancing autophagy flux and clearing protein aggregates.

PF-D-Trimer, a broadly protective SARS-CoV-2 subunit vaccine: immunogenicity and application

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

Selective Control of Parasitic Nematodes Using Bioactivated Nematicides

This study identifies selectivins, a family of imidazothiazole nematicides that are selectively activated in nematodes, offering effective and selective control of plant-parasitic nematodes.

Structural Insights into Sphingosine-1-phosphate Receptor Activation

This study reports cryo-EM structures of S1PR1 bound to different agonists, revealing activation mechanisms and a two-step transition process for CBP-307.

SILAC phosphoproteomics reveals unique signaling circuits in CAR-T cells and the inhibition of B cell-activating phosphorylation in target cells

The paper uses SILAC phosphoproteomics to compare signaling changes in CAR-T cells and target B cells, finding unique phosphorylation patterns in CAR-T cells and reduced B cell receptor signaling in target cells.

Exosome component 1 cleaves single-stranded DNA and sensitizes kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor

This study identifies EXOSC1 as an endogenous source of mutation in KIRC that promotes DNA damage and sensitizes cells to PARP inhibitors.

Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching and cofilin dependent podosome formation

This study shows that matrix stiffness and blood pressure together drive vascular smooth muscle cell phenotypic switching and cofilin-dependent podosome formation in atherosclerosis.

Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

PCV2 aggravated SS2 infection directly showed from differentially expressed proteome of PK15 cells.

The paper shows PCV2 worsens SS2 infection in PK15 cells through differentially expressed proteins and pathway analysis.

Toxic Effects of Crude Extracts from Chinese Herbal Toothpastes on Solenopsis invicta (Hymenoptera: Formicidae)

This study evaluates the toxicity of Chinese herbal toothpaste and its extracts on red imported fire ants, finding significant mortality rates and suggesting potential for bait use in pest control.

Circulating bacterial DNA as a tool towards non-invasive biomarkers for colorectal cancer and adenoma

This study identifies circulating bacterial DNA biomarkers for colorectal cancer and adenoma using plasma samples and a random forest model, achieving high accuracy in distinguishing between cancer, adenoma, and healthy controls.