bioRxivPhysiologyPreprint
Globin digest and its constituent peptides promote skeletal muscle hypertrophy and enhance physical performance
Misa Nakai, Liqing ZangiD, Kazutake Fukada, Keiichi Ishido, Norihiro NishimuraiD, Yasuhito ShimadaiD
Abstract
Globin digest (GD), an acidic protease hydrolysate of hemoglobin, has been recognized for its anti-obesity and glucose-modulating effects; however, its direct anabolic potential in skeletal muscle remains uncharacterized. We evaluated the effects of GD and its constituent peptides on muscle hypertrophy and motor function using zebrafish, mice, and C2C12 myoblasts. Adult zebrafish administered GD (400 mg/kg BW/d) for 1 week showed significantly increased swimming distance (p View larger version (48K): org.highwire.dtl.DTLVardef@94675borg.highwire.dtl.DTLVardef@10dbbfaorg.highwire.dtl.DTLVardef@b026eforg.highwire.dtl.DTLVardef@cc4058_HPS_FORMAT_FIGEXP M_FIG C_FIG
- organism: zebrafish
- organism: mouse
- assay: proteomics
- research focus: cell type annotation
- research focus: cell signaling & trafficking
- research focus: metabolism & bioenergetics
- research focus: cancer & tumor microenvironment
- approach: experimental assay
- Citations
- 0
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