henhao
Sign in
Genetic & Genomic MedicinePediatric Research
Peer-reviewed journal article

Can leptin-specific epigenetic modulation of preterm cord blood predispose obesity?

Navya Sree BogaiD, Amit Kumar Banerjee, Saikanth VarmaiD, Archana Molangiri, Syeda Farhana, Santosh Kumar BanjaraiD, Nitasha BaggaiD, Asim K. DuttaroyiD, Sanjay BasakiD

Abstract

ObjectiveThis retrospective cohort investigated the role of leptins promoter methylation and microRNA targeting profile in developing adiposity and inflammation in neonates, using umbilical cord blood from preterm (n=67) and term (n=71) mothers. MethodsGlobal DNA methylation and leptin promoter methylation were performed. ELISA determined leptin and IGF1 levels. Real-time PCR measured mRNA levels. MicroRNA target prediction on the human leptin gene (LEP) was done in silico using network analysis. ResultsPreterm cord blood significantly reduced genome-wide (p View larger version (11K): org.highwire.dtl.DTLVardef@1f3604corg.highwire.dtl.DTLVardef@13723b5org.highwire.dtl.DTLVardef@1094bfborg.highwire.dtl.DTLVardef@15b5ebc_HPS_FORMAT_FIGEXP M_FIG C_FIG

PDFDOI

02 /Specification & Classification

Click any tag to browse matching papers
Citations
1
FWCI
10.20
Field percentile
top 3%
OpenAlex Topics

Reproducibility ledger

Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.

Sign in to file a reproducibility report.

Related papers

Similarity Map
SelectedSame fieldCross-field
THISMüller '25Larivière '24Schlueter '20Sureshchand '22Messaoudi '20Wu '25
62% semantic matchGenetics
Luise Müller, Rebecca Oelkrug, Jens Mittag+11 more·Clinical Epigenetics·Feb 11, 2025· 2 citations