Birth, Development, and Health

Sustained Maternal Cortisol Elevation Links Metabolic Stress to Fetal Growth Restriction in a Guinea Pig Model of Undernutrition

This study shows that maternal cortisol elevation due to stress mediates fetal growth restriction in undernourished guinea pigs, beyond just nutrient limitation.

Cross-generational characterization of paternal Low Protein Diet effects in mice

This study examines how paternal low protein diet affects mice across generations, revealing sex-specific metabolic changes and intergenerational inheritance patterns.

Maternal obesity accelerates cardiomyocyte maturation and programs adult heart dysfunction in offspring

This study shows maternal obesity accelerates cardiomyocyte maturation in offspring, leading to adult heart dysfunction through cytoarchitectural disruption.

Maternal hyperglycemia impairs postnatal skeletal muscle growth and induces stage-dependent gene expression changes in mouse offspring

This study shows maternal hyperglycemia impairs skeletal muscle growth in offspring at 4 and 8 weeks, with distinct gene expression changes at each stage.

Prenatal Inflammation as a Determinant of Long-Term Cardiovascular Risk: Evidence from a Murine Model

This study shows that prenatal inflammation in mice leads to long-term cardiovascular issues in offspring, including hypertension and vascular changes.

Sex-Dependent Epigenomic and Transcriptomic Reprogramming Links Maternal Obesity to Cardiac Remodeling in Adult Offspring

This study shows maternal obesity causes sex-dependent epigenetic and transcriptomic changes in offspring hearts, leading to sex-specific cardiac remodeling and disease risk.

Intrauterine growth restriction is associated with adaptive hematopoietic reprogramming and selective immune rewiring in monozygotic twins

The paper identifies adaptive hematopoietic and immune reprogramming in discordant monozygotic twins with intrauterine growth restriction through transcriptomic and epigenomic analyses.

Placental DNA methylation captures shared and trait-specific genetic susceptibility across complex health conditions

This study constructs a high-resolution placental mQTL resource and investigates how placental DNA methylation relates to early- and later-life traits and their shared vulnerability.

The E2F1 regulon orchestrates a proliferative emergency and vascular programming in fetal endothelial progenitors exposed to GDM: a sex-stratified systems medicine approach

The paper identifies the E2F1 regulon as a driver of sex-specific vascular programming in fetal endothelial progenitors exposed to GDM, revealing a proliferative emergency in females.

Insulin modulates mPFC gene expression and emotional behavior in a sex-specific manner following fetal growth restriction

This study shows insulin signaling links prenatal adversity to long-term brain and behavioral changes, with sex-specific effects in rats.

Maternal BMI and Placental Transcriptomic Changes: A Meta-Analysis of Gene Expression at the Maternal-Fetal Interface

This paper identifies placental transcriptomic changes associated with maternal BMI through a meta-analysis of RNA-seq data, finding significant genes and pathways linked to inflammation and metabolism.

Perinatal Semaglutide Treatment Improves Maternal Health and Mitigates Offspring Metabolic Dysfunction in a Mouse Model of Maternal Obesity

Can leptin-specific epigenetic modulation of preterm cord blood predispose obesity?

The paper examines if leptin promoter methylation in preterm cord blood is associated with adiposity and inflammation in neonates.

Effects of Maternal Obesity on Fetal Cerebral Glucose Transporter Expression

This study investigates how maternal obesity affects fetal brain glucose transporter expression and energy-sensing pathways in mice, finding altered GLUT expression without changes in key regulatory pathways.

Early life environments shape adult cardiometabolic health during rapid lifestyle change

The paper examines how early life environments affect adult cardiometabolic health in the Orang Asli, finding support for developmental constraints over predictive adaptive responses.

Direct and Indirect Genetic Effects of Birthweight Predisposition on Child DNA Methylation at Birth

This study investigates whether genetic birthweight predisposition, through direct or indirect effects, is associated with DNA methylation at birth and identifies six methylation sites linked to maternal indirect effects.

Early impact of gestational protein restriction on nephrogenesis in male mouse offspring: Role of Autophagy and Apoptosis Mechanisms

This study examines how low-protein diets during pregnancy affect kidney development in male mouse offspring, showing changes in gene expression, autophagy, and nephron numbers by gestational day 18.

Offspring effect of maternal preconception exposure to metabolic disruptors

This study investigates whether preconception exposure to metabolic disruptors in mice leads to metabolic and psychiatric alterations in offspring.

Spontaneous Pregravid Obesity Reshapes Fetal Immune Ontogeny in a Nonhuman Primate Model

This study shows that pregravid obesity in rhesus macaques alters fetal immune development, leading to immune dysregulation and increased disease susceptibility in offspring.

Maternal preconception calorie restriction reprograms coping strategies, socio-sexual behaviour, and endocrine function in adult rat offspring

This study shows that maternal preconception calorie restriction affects adult offspring behavior and endocrine function differently in males and females.

Exposure of male mice to nicotine leads to metabolic dysfunction in their male and female offspring

This study shows paternal nicotine exposure causes sex-dependent metabolic changes in offspring, affecting glucose homeostasis in females and liver function in males.

Maternal Obesity Decreases Offspring Lifespan

This study shows maternal obesity reduces offspring lifespan in mice, linked to early developmental fibrotic changes across multiple organs.

A Multi-tissue Transcriptomic-Metabolomic Map Linking Maternal High-Fiber Diet to Reduced Offspring Type 2 Diabetes

This paper links maternal high-fiber diet to reduced offspring type 2 diabetes risk through multi-tissue transcriptomic and metabolomic analyses in Nile rats, identifying ASNSD1 as a key gene involved.

Regular parental exercise before mating influences offspring lower adiposity associated to hypothalamic neurodevelopmental changes

This study shows that parental exercise before mating reduces offspring adiposity and affects hypothalamic gene expression in mice.

Maternal Western-style Diet Promotes Immune Tolerance and Liver Sinusoidal Endothelial Cell Dysfunction in Nonhuman Primate Juvenile Offspring Liver

This study shows that maternal Western-style diet during pregnancy and lactation alters immune and endothelial cell function in juvenile nonhuman primate offspring livers, promoting immune tolerance and fibrosis.

Maternal sucrose intake during pregnancy alone disrupts testosterone and allopregnanolone levels in the fetal brain of rats

This study shows that maternal high-sucrose diet during pregnancy alters fetal brain steroid levels but not maternal or fetal blood steroids.

Maternal protein restriction alters chromatin accessibility in neuroprogenitors of the fetal hypothalamus of rats.

This study identifies altered chromatin accessibility in fetal rat hypothalamic neuroprogenitors due to maternal protein restriction, affecting gene regulation and developmental pathways.

Placental Igf1 Overexpression Sex-Specifically Impacts Mouse Placenta Structure, Altering Offspring Striatal Development and Behavior

This study shows that placental Igf1 overexpression affects mouse placenta structure differently in males and females, leading to sex-specific changes in striatal development and behavior.

Sex, Stress and the Heart: Long-term Cardiovascular Effects of Embryonic Metabolic Disruption

This study examines how embryonic hypoxia and hypothermia affect cardiovascular structure and function in chickens, revealing sex-specific differences in mitochondrial morphology and ventricular hypertrophy.

Birth weight discordance, gene expression, and DNA methylation: A review of epigenetic twin studies

This paper reviews epigenetic twin studies linking birth weight discordance to gene expression and DNA methylation, highlighting growth-related genes and epigenetic mechanisms.