Author

I. Messaoudi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 15 Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 14 Research Focus:cell type annotation· 12 Assay:bulk RNA-seq· 9 Research Focus:differential expression· 9 Approach:statistical model· 9 Research Focus:host-pathogen & immune response· 8 Organism:human· 8 Organism:rat· 8

Frequent Co-Authors

S. Sureshchandra· 9 shared B. M. Doratt· 7 shared A. Jankeel· 6 shared N. E. Marshall· 6 shared S. A. Lewis· 6 shared I. R. Cinco· 5 shared M. Rincon· 5 shared N. S. Rhoades· 5 shared

Activity by Year

2020-2023 · peak 8/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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9 shared papersImmunology

S. Sureshchandra

Mutual co-authors in cluster

Author profile →

20 papers

Recent·Most cited

Mild/Asymptomatic Maternal SARS-CoV-2 Infection Leads to Immune Paralysis in Fetal Circulation and Immune Dysregulation in Fetal-Placental Tissues

B. M. Doratt, S. Sureshchandra, H. True, M. Rincon, N. E. Marshall, I. Messaoudi

This study examines the effects of mild maternal SARS-CoV-2 infection on fetal immune responses, finding altered inflammatory mediators and immune cell activation in cord blood and placental tissues.

bioRxiv · May 10, 2023 · PreprintImmunology

Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung

S. A. Lewis, I. R. Cinco, B. M. Doratt, M. B. Blanton, C. Hoagland, M. Davies, K. A. Grant, I. Messaoudi

This study shows chronic alcohol consumption reduces antiviral cytokine induction and disrupts TLR signaling in lung cells from humans and rhesus macaques infected with SARS-CoV-2.

bioRxiv · May 2, 2023Immunology

Integrated single cell analysis shows chronic alcohol drinking disrupts monocyte differentiation in the bone marrow niche

S. A. Lewis, B. M. Doratt, Q. Qiao, M. B. Blanton, K. A. Grant, I. Messaoudi

This study shows chronic alcohol consumption disrupts monocyte differentiation in the bone marrow niche, leading to heightened inflammation and compromised anti-microbial defenses in circulating monocytes.

bioRxiv · Mar 29, 2023Immunology

Impact of aging on the immunological and microbial landscape of the lung during non-tuberculous mycobacterial infection

I. R. Cinco, N. S. Rhoades, E. G. Napier, M. Davies, D. B. Allison, S. G. Kohama, L. E. Bermudez, K. Winthrop, C. Fuss, E. R. Spindel, I. Messaoudi

This study investigates how aging affects the immune and microbial environment in the lungs during NTM infection using a rhesus macaque model.

bioRxiv · Feb 11, 2023 · PreprintImmunology

SARS-CoV-2 Vaccine Booster Elicits Robust Prolonged Maternal Antibody Responses and Passive Transfer Via The Placenta And Breastmilk

N. E. Marshall, M. B. Blanton, B. M. Doratt, D. C. Malherbe, M. Rincon, H. True, T. McDonald, C. Beauregard, R. Adatorwovor, I. Messaoudi

This study evaluates maternal SARS-CoV-2 vaccine antibody responses in circulation and breastmilk, showing that boosters increase antibody levels for passive transfer to newborns.

bioRxiv · Nov 29, 2022 · PreprintImmunology

Multimodal profiling of term human decidua reveals tissue-specific immune adaptations with maternal obesity

S. Sureshchandra, B. M. Doratt, N. Mendoza, M. Rincon, N. E. Marshall, I. Messaoudi

The paper constructs an immune cell atlas of term decidua and identifies alterations in immune cell composition and function associated with pregravid maternal obesity.

bioRxiv · Nov 1, 2022 · PreprintImmunology

Impact of pregravid obesity on anti-microbial fetal monocyte response

S. Sureshchandra, B. M. Doratt, N. Mendoza, O. Varlamov, M. Rincon, N. E. Marshall, I. Messaoudi

This study shows that maternal pregravid obesity impairs fetal monocyte responses to bacterial and viral pathogens through epigenetic and signaling defects.

bioRxiv · Jul 10, 2022Immunology

Therapeutic neutralizing monoclonal antibody administration protects against lethal viscerotropic Yellow Fever infection

M. J. Ricciardi, L. N. Rust, N. Pedreno-Lopez, S. Yusova, S. Biswas, G. M. Webb, M. Fischer, L. Gonsales-Nieto, T. B. Voigt, J. J. Louw, F. D. Laurino, J. R. DiBello, H.-P. Raue, L. M. S. Raphael, A. Yrizarry-Medina, , B. J. Burwitz

Therapeutic monoclonal antibodies prevent death from YFV infection.

bioRxiv · May 16, 2022 · PreprintImmunology

Taxonomic and functional shifts in the perinatal gut microbiome of rhesus macaques

N. S. Rhoades, I. R. Cinco, S. M. Hendrickson, M. K. Slifka, I. Messaoudi

This study examines taxonomic and functional changes in the gut microbiome of rhesus macaques during pregnancy and postpartum, finding significant shifts in microbial composition and metabolic pathways.

bioRxiv · Mar 2, 2022Microbiology

Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging: insights from rhesus macaques

N. S. Rhoades, M. Davies, S. A. Lewis, I. R. Cinco, S. G. Kohama, L. E. Bermudez, K. L. Winthorp, C. Fuss, J. A. Mattison, E. R. Spindel, I. Messaoudi

This study examines age-related changes in lung function, immunity, and microbiota in rhesus macaques, revealing shifts in immune cell populations and microbial composition associated with healthy aging.

bioRxiv · Feb 8, 2022 · PreprintImmunology

Deep immune profiling of the maternal-fetal interface with mild SARS-CoV-2 infection

S. Sureshchandra, M. Z. Zulu, B. Doratt, A. Jankeel, D. Tifrea, R. A. Edwards, M. Rincon, N. E. Marshall, I. Messaoudi

This study examines immune changes in pregnant women with mild SARS-CoV-2 infection, finding altered immune responses in blood and decidua that may impact fetal development.

bioRxiv · Aug 23, 2021 · PreprintImmunology

Chronic ethanol drinking in non-human primates induces inflammatory cathepsin gene expression in alveolar macrophages accompanied by functional defects

S. A. Lewis, B. Doratt, S. Sureshchandra, A. Jankeel, N. Newman, K. A. Grant, I. Messaoudi

This study shows chronic ethanol drinking in rhesus macaques increases inflammatory gene expression and functional defects in alveolar macrophages, linking to increased infection susceptibility.

bioRxiv · Jul 30, 2021 · PreprintImmunology

Single cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine

S. Sureshchandra, S. A. Lewis, B. Doratt, A. Jankeel, I. Ibraim, I. Messaoudi

This study compares the adaptive immune response to SARS-CoV-2 mRNA vaccine and natural infection, finding robust CD4 T and B cell responses but weak and variable CD8 T cell responses.

bioRxiv · Jul 14, 2021Immunology

Pathogenic and transcriptomic differences of emerging SARS-CoV-2 variants in the Syrian golden hamster model

K. L. O'Donnell, A. N. Pinski, C. S. Clancy, T. Gourdine, K. Shifflett, P. Fletcher, I. Messaoudi, A. Marzi

This study compares the pathogenic and transcriptomic effects of SARS-CoV-2 variants B.1.1.7 and B.1.351 to the ancestral strain in Syrian golden hamsters, finding distinct humoral responses and transcriptional profiles.

bioRxiv · Jul 11, 2021Microbiology

Acute SARS-CoV-2 infection is associated with an expansion of bacteria pathogens in the nose including Pseudomonas aeruginosa

N. S. Rhoades, A. Pinski, A. N. Monsibais, A. Jankeel, B. M. Doratt, I. R. Cinco, I. Ibraim, I. Messaoudi

This study finds that acute SARS-CoV-2 infection is linked to increased nasal bacterial pathogens, particularly Pseudomonas aeruginosa, and a host transcriptional response, but not viral sequence variation.

bioRxiv · May 20, 2021Microbiology

Transcriptional, epigenetic, and functional reprogramming of blood monocytes in non-human primates following chronic alcohol drinking

S. A. Lewis, S. Sureshchandra, B. Doratt, V. Jimenez, C. Stull, K. A. Grant, I. Messaoudi

This study examines how chronic alcohol drinking affects monocytes and macrophages in non-human primates, revealing hyper-inflammatory responses and impaired function.

bioRxiv · May 12, 2021Immunology

Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus Macaques

S. Sureshchandra, C. N. Chan, J. J. Robino, L. K. Parmelee, M. J. Nash, S. R. Wesolowski, E. M. Pietras, J. E. Friedman, D. Takahashi, W. Shen, J. D. Hennebold, D. Goldman, W. Packwood, J. R. Lindner, C. T. Roberts, , O. Varlamov

This study shows that a maternal Western-style diet impairs fetal bone marrow development and causes hyperinflammation and B-cell dysfunction in fetal hematopoietic stem and progenitor cells in rhesus macaques.

bioRxiv · Apr 26, 2021 · PreprintImmunology

Rapid protection from COVID-19 in nonhuman primates vaccinated intramuscularly but not intranasally with a single dose of a recombinant vaccine

W. Furuyama, K. Shifflett, A. N. Pinksi, A. J. Griffin, F. Feldmann, A. Okumura, T. Gourdine, A. Jankeel, J. Lovaglio, P. W. Hanley, T. Thomas, C. S. Clancy, I. Messaoudi, K. L. O'Donnell, A. Marzi

A single-dose VSV-based vaccine protected nonhuman primates from COVID-19 within 10 days when administered intramuscularly but not intranasally.

bioRxiv · Jan 19, 2021 · PreprintMicrobiology

Longitudinal profiling of the macaque vaginal microbiome reveals similarities to diverse human vaginal communities: implications for use as a pre-clinical model for bacterial vaginosis

N. S. Rhoades, S. M. Hendrickson, D. R. Gerken, K. Martinez, O. D. Slayden, M. K. Slifka, I. Messaoudi

This study shows that rhesus macaques have vaginal microbiomes similar to human BV-associated communities, supporting their use as a pre-clinical model for studying bacterial vaginosis.

bioRxiv · Dec 14, 2020Microbiology

Functional and genomic adaptations of blood monocytes to pregravid obesity during pregnancy

I. Messaoudi, S. Sureshchandra, N. E. Marshall, N. Mendoza, A. Jankeel, M. Z. Zulu

This study examines how pregravid obesity affects immune responses during pregnancy, finding that it disrupts immune activation and promotes immunotolerance.

bioRxiv · Dec 2, 2020Immunology