Author

B. M. Doratt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 5 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Approach:statistical model· 4 Research Focus:host-pathogen & immune response· 3 Organism:rat· 3

Frequent Co-Authors

I. Messaoudi· 7 shared M. Rincon· 4 shared N. E. Marshall· 4 shared M. B. Blanton· 3 shared S. Sureshchandra· 3 shared H. True· 2 shared I. R. Cinco· 2 shared K. A. Grant· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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7 shared papersImmunology

I. Messaoudi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mild/Asymptomatic Maternal SARS-CoV-2 Infection Leads to Immune Paralysis in Fetal Circulation and Immune Dysregulation in Fetal-Placental Tissues

B. M. Doratt, S. Sureshchandra, H. True, M. Rincon, N. E. Marshall, I. Messaoudi

This study examines the effects of mild maternal SARS-CoV-2 infection on fetal immune responses, finding altered inflammatory mediators and immune cell activation in cord blood and placental tissues.

bioRxiv · May 10, 2023 · PreprintImmunology

Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung

S. A. Lewis, I. R. Cinco, B. M. Doratt, M. B. Blanton, C. Hoagland, M. Davies, K. A. Grant, I. Messaoudi

This study shows chronic alcohol consumption reduces antiviral cytokine induction and disrupts TLR signaling in lung cells from humans and rhesus macaques infected with SARS-CoV-2.

bioRxiv · May 2, 2023Immunology

Integrated single cell analysis shows chronic alcohol drinking disrupts monocyte differentiation in the bone marrow niche

S. A. Lewis, B. M. Doratt, Q. Qiao, M. B. Blanton, K. A. Grant, I. Messaoudi

This study shows chronic alcohol consumption disrupts monocyte differentiation in the bone marrow niche, leading to heightened inflammation and compromised anti-microbial defenses in circulating monocytes.

bioRxiv · Mar 29, 2023Immunology

SARS-CoV-2 Vaccine Booster Elicits Robust Prolonged Maternal Antibody Responses and Passive Transfer Via The Placenta And Breastmilk

N. E. Marshall, M. B. Blanton, B. M. Doratt, D. C. Malherbe, M. Rincon, H. True, T. McDonald, C. Beauregard, R. Adatorwovor, I. Messaoudi

This study evaluates maternal SARS-CoV-2 vaccine antibody responses in circulation and breastmilk, showing that boosters increase antibody levels for passive transfer to newborns.

bioRxiv · Nov 29, 2022 · PreprintImmunology

Multimodal profiling of term human decidua reveals tissue-specific immune adaptations with maternal obesity

S. Sureshchandra, B. M. Doratt, N. Mendoza, M. Rincon, N. E. Marshall, I. Messaoudi

The paper constructs an immune cell atlas of term decidua and identifies alterations in immune cell composition and function associated with pregravid maternal obesity.

bioRxiv · Nov 1, 2022 · PreprintImmunology

Impact of pregravid obesity on anti-microbial fetal monocyte response

S. Sureshchandra, B. M. Doratt, N. Mendoza, O. Varlamov, M. Rincon, N. E. Marshall, I. Messaoudi

This study shows that maternal pregravid obesity impairs fetal monocyte responses to bacterial and viral pathogens through epigenetic and signaling defects.

bioRxiv · Jul 10, 2022Immunology

Acute SARS-CoV-2 infection is associated with an expansion of bacteria pathogens in the nose including Pseudomonas aeruginosa

N. S. Rhoades, A. Pinski, A. N. Monsibais, A. Jankeel, B. M. Doratt, I. R. Cinco, I. Ibraim, I. Messaoudi

This study finds that acute SARS-CoV-2 infection is linked to increased nasal bacterial pathogens, particularly Pseudomonas aeruginosa, and a host transcriptional response, but not viral sequence variation.

bioRxiv · May 20, 2021Microbiology