Oxidative stress resistance and fitness-compensatory response in vancomycin-intermediate Staphylococcus aureus (VISA)
Abstract
In this study, VISA cells carrying vraS and/or graR mutations were shown to be more resistant to oxidative stress. Caenorhabditis elegans infected with these strains in turn demonstrated lower survival. Altered regulation in oxidative stress response and virulence appears to be physiological adaptations associated with VISA phenotype in the Mu50 lineage.
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