A. M. Edwards

A resource to enable chemical biology and drug discovery of WDR Proteins

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

IS1-related large-scale deletion of chromosomal regions harbouring oxygen-insensitive nitroreductase gene nfsB causes nitrofurantoin heteroresistance in Escherichia coli

The paper identifies IS1-mediated chromosomal deletions in nfsB as a novel mechanism of nitrofurantoin heteroresistance in E. coli.

Antimicrobial peptide glatiramer acetate targets Pseudomonas aeruginosa lipopolysaccharides to breach membranes without altering lipopolysaccharide modification

This study shows glatiramer acetate binds and neutralizes Pseudomonas aeruginosa lipopolysaccharides and extracellular DNA, enhancing antibiotic efficacy without inducing resistance mechanisms.

Host-induced cell wall remodelling impairs opsonophagocytosis of Staphylococcus aureus by neutrophils

This study shows that S. aureus adapts to the host by thickening its cell wall, reducing opsonin exposure and impairing neutrophil phagocytosis and killing.

Human serum induces daptomycin tolerance in Enterococcus faecalis and viridans group streptococci

This study shows human serum induces daptomycin tolerance in Enterococcus faecalis and viridans group streptococci, which can be mitigated by fosfomycin or combination therapy.

XerC is required for the repair of antibiotic- and immune-mediated DNA damage in Staphylococcus aureus

This study identifies XerC as essential for DNA repair in Staphylococcus aureus, increasing susceptibility to antibiotics and immune defenses.

E. faecalis acquires resistance to antimicrobials and insect immunity via common mechanisms

The paper shows that E. faecalis develops resistance to both antimicrobials and host immunity through shared mechanisms, without requiring antibiotic exposure.

Growth arrest of Staphylococcus aureus induces daptomycin tolerance via cell wall remodelling

This study shows that growth arrest of S. aureus increases daptomycin tolerance through cell wall remodelling, not just passive metabolic inactivity.

A statistical censoring approach accounts for hook competition in abundance indices from longline surveys

The paper introduces a statistical censoring method to correct for hook competition bias in longline survey abundance indices, showing significant improvements over existing methods.

An open source plant kinase chemogenomics set

The paper presents a plant kinase chemogenomics set, identifying compounds that affect root development in Arabidopsis and rice, with implications for understanding plant kinase function.

Synergistic Activity of Repurposed Peptide Drug Glatiramer Acetate with Tobramycin Against Cystic Fibrosis Pseudomonas aeruginosa

This study shows that glatiramer acetate enhances tobramycin's effectiveness against Pseudomonas aeruginosa in cystic fibrosis patients by reducing MICs and disrupting bacterial membranes.

Human serum triggers antibiotic tolerance in Staphylococcus aureus

This study shows human serum induces antibiotic tolerance in MRSA through two mechanisms involving cell wall changes and membrane composition, suggesting fosfomycin could enhance daptomycin efficacy.

Colistin resistance in Escherichia coli confers protection of the cytoplasmic but not outer membrane from the polymyxin antibiotic

This study shows that colistin resistance in E. coli protects the cytoplasmic but not outer membrane from colistin, regardless of resistance mechanism.

A Functional Menadione Biosynthesis Pathway is Required for Capsule Production by Staphylococcus aureus.

This study identifies menD as a regulator of capsule production in S. aureus through GWAS and functional validation, showing its role in gentamicin resistance without major growth defects.

In pursuit of a better broiler: A comparison of the inactivity, behavior, and enrichment use of fast- and slower-growing broiler chickens

This study compares inactivity, behavior, and enrichment use in fast- and slower-growing broiler chickens, finding that faster-growing strains are more inactive and use enrichment less, especially at younger ages.

Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

This study reveals that colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane, not the outer membrane, and shows that murepavadin can enhance its efficacy.

Multiple classes of bactericidal antibiotics cause DNA double strand breaks in Staphylococcus aureus

This study shows that multiple antibiotic classes induce DNA double strand breaks in Staphylococcus aureus, which are repaired by the RexAB complex, enhancing bacterial survival.

In Pursuit of a Better Broiler: Growth, Efficiency and Mortality of 16 Strains of Broiler Chickens

This study compares growth, efficiency, and mortality of 16 broiler chicken strains reared under standardized conditions, finding differences in weight and feed efficiency but not mortality.

Effect of host-mimicking medium and biofilm growth on the ability of colistin to kill Pseudomonas aeruginosa.

This study shows that Pseudomonas aeruginosa in CF-mimicking media and ex vivo models exhibits higher colistin tolerance due to poor antibiotic penetration, highlighting the need for better biofilm penetration assays.

Staphylococcal DNA repair is required for infection

This study identifies DNA repair mechanisms in Staphylococcus aureus essential for survival during infection, showing that host immune cells induce DNA damage repaired by RexAB.

RexAB is essential for the mutagenic repair of Staphylococcus aureus DNA damage caused by co-trimoxazole

This study shows that co-trimoxazole causes DNA damage in S. aureus through thymidine limitation and oxidative stress, which is repaired by the RexAB complex, leading to mutagenesis and antibiotic resistance.

The electron transport chain sensitises Staphylococcus aureus and Enterococcus faecalis to the oxidative burst

The paper shows that loss of the electron transport chain in Staphylococcus aureus and Enterococcus faecalis SCVs increases resistance to the oxidative burst in human blood.

Enterococcus faecalis and pathogenic streptococci inactivate daptomycin by releasing phospholipids

This study shows that Enterococcus faecalis and other Gram-positive bacteria release phospholipids to inactivate daptomycin, reducing the antibiotic's effectiveness.