The case for absolute ligand discrimination : modeling information processing and decision by immune T cells

1. Introduction 1. Introduction 2. Theoretical approaches for... 3. Biologically realistic models... 4. Ligand recognition by... 5. Wrapping up References Cells within the body are constantly bombarded with a large repertoire of molecules that must be dealt with as potential stimuli. Most of the time, these molecular inputs are measured by receptors at the surface of the cells. State of these receptors are thus informative on the outside world, and experimental and theoretical biophysicists [50] have extensively used information theory to estimate how much information (in the Shannon sense [45]) can be encoded at this stage. This information can be used and processed by the cells, and again transmission of information between Inputs and Outputs have been well studied (see e ...