Author

R. A. Fernandes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. A. Carr· 1 shared A. E. Lindsay· 1 shared A. M. Santos· 1 shared A. Ponjavic· 1 shared A. Tilevik· 1 shared B. C. Lagerholm· 1 shared C. B. Carbone· 1 shared C. Macleod· 1 shared

Activity by Year

2017-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

A. A. Carr

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2 papers

Recent·Most cited

A cell-topography based mechanism for ligand discrimination by the T-cell receptor

R. A. Fernandes, K. A. Ganzinger, J. Tzou, P. Jonsson, S. F. Lee, M. Palayret, A. M. Santos, A. A. Carr, A. Ponjavic, V. T. Chang, C. Macleod, B. C. Lagerholm, A. E. Lindsay, O. Dushek, A. Tilevik, , D. Klenerman

This paper develops a model showing T-cell receptors discriminate ligands based on dwell-time in phosphatase-depleted contacts constrained by cell topography, predicting signaling potency without multi-step proof-reading.

bioRxiv · Nov 19, 2018Immunology

In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase

C. B. Carbone, N. Kern, R. A. Fernandes, E. Hui, X. Su, K. C. Garcia, R. Vale

This paper demonstrates that TCR-pMHC and PD-1-PD-L1 interactions can exclude CD45 from membrane interfaces, creating spatial organization that may regulate T cell signaling.

bioRxiv · Jun 7, 2017Immunology