M. Meyer-Hermann

Suppressive might of a few: T follicular regulatory cells impede auto-reactivity despite being outnumbered in the germinal centres

This study uses simulations to show how T follicular regulatory cells (Tfrs) suppress self-reactive B cells in germinal centers by inducing apoptosis and regulating differentiation, with outcomes dependent on Tfr location and number.

High-resolution mapping of cell-cycle dynamics during T-cell development and regeneration in vivo

This study maps cell-cycle dynamics during T-cell development and regeneration using in vivo labeling and modeling, revealing phase adjustments that maintain homeostasis.

Amount of antigen, T follicular helper cells and quality of seeder cells shape the diversity of germinal center B cells

This study uses an agent-based model to show that antigen availability, T follicular helper cells, and high-affinity founder cells influence germinal center B cell diversity and affinity maturation.

Rate of immune complex cycling in follicular dendritic cell determines the extent of protecting antigen integrity and availability to germinal center B cells

The paper estimates immune complex cycling rates in follicular dendritic cells and shows how this affects antigen protection and germinal center dynamics.

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells

This study identifies cyclin D3 as essential for inertial cell cycling in dark zone germinal center B cells, enabling clonal expansion and linking it to potential lymphoproliferative disorders.

Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development

This study investigates how influenza A virus-induced thymus atrophy affects Treg cell development and shows a relative increase in tTreg cells with reduced TCR diversity.

Intrinsic defects in lymph node stromal cells underpin poor germinal center responses during aging

This study shows that aging impairs lymph node stromal cells' ability to respond to vaccination, limiting germinal center formation and antibody production.

Investigating the physical effects in bacterial therapies for avascular tumors

This study develops a mathematical model to analyze how physical effects, such as bacterial chemotaxis and killing rates, influence the effectiveness of bacterial therapy in avascular tumors.

An adaptive control scheme for Interleukin-2 therapy

This paper develops an adaptive control strategy for IL-2 therapy to stabilize Treg populations and limit Tconv responses using a mechanistic model.

Germinal center B cells separate signals for selectionand division like compact discs

The paper unifies contradictory B cell selection experiments by separating signals for fate decision frequency from division strength, proposing three testable theories of B cell selection.

In silico characterization of mechanisms positioning costimulatory and checkpoint complexes in immune synapses

The paper uses computer simulations to reveal how immunoglobulin superfamily adhesion and costimulatory/checkpoint complexes are localized in immunological synapses.

CD2 expression acts as a quantitative checkpoint for immunological synapse structure and T-cell activation.

The paper shows CD2 expression levels determine immunological synapse structure and T-cell activation by influencing CD2-CD58 localization and Src-family kinase recruitment.

Injection of antibodies against immunodominant epitopes tunes germinal centres to generate broadly neutralizing antibodies

The paper uses computer simulations to show that injecting antibodies against immunodominant epitopes can promote the generation of broadly neutralizing antibodies by focusing germinal centers on new epitopes.

On the impact of chemo-mechanically induced phenotypic transitions in gliomas

This study examines how mechanical compression affects glioma cell migration and proliferation, and develops a model showing a trade-off between tumor infiltration and cellular content in response to stress-alleviation strategies.