Chronic semaglutide treatment attenuates cue-induced reinstatement of cocaine-seeking and cocaine-induced stereotypy in male and female rats
Christopher A. TurneriD, Natalia Morales Pagan, Daniela Pereira, Eileen Y Sun, Rachel E. Himelhoch, Stephen E. Chang, Shelly B. FlageliD
Abstract
Following cocaine self-administration, male and female rats received daily semaglutide during a 30-day abstinence period before cue- and cocaine-induced reinstatement tests. Semaglutide attenuated cue-induced reinstatement and cocaine-induced stereotypy, although operant responding was elevated following cocaine priming. These findings support further investigation of semaglutide as a treatment for cocaine use disorder.
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