Oscillations synchronize amygdala-to-prefrontal primate circuits during aversive learning

The contribution of oscillatory synchrony in the primate amygdala-prefrontal pathway to aversive learning remains unknown. We found increased power and phase synchrony in the theta range during aversive conditioning. The synchrony was linked to single-unit spiking and exhibited specific directionality between input and output measures in each region. Although it was correlated with the development of conditioned responses, it declined once the association stabilized. The results suggest that amygdala spikes aid to synchronize ACC activity and transfer error-signal information to support memory formation.\n\nHighlightsO_LITone-odor conditioning induces theta phase-reset in primate amygdala and dACC\nC_LIO_LIA directional phase-locking develops between amygdala spikes and dACC Theta\nC_LIO_LIInformation transfer from Amygdala to dACC decreases once memory stabilizes\nC_LI