In Vitro Anti-cancer potential of Aloe emodin against Oral Squamous Cell Carcinoma

Abstract

Oral squamous cell carcinoma is caused due to smoking, chewing of tobacco, high exposure of UV radiation and infectious agents such as human papilloma virus (HPV). Epigenetic dysregulation and uncontrolled cell growth are main factors that drives towards tumor development. Risk factors such as smoking, tobacco and viral agents up regulates its activity and leads to the cancer. Although chemotherapy, surgery and radiation were preferred for treating cancer but patients, feel extreme psychological stress and depression. Natural products are been investigated for their numerous diseases and in that they can be treated against cancer without side effects. Aloe emodin is one such natural molecule available, which possess various pharmacological activities for human beneficial. In this current study, we investigated the anti-cancer activity of aloe emodin in vitro. The KB 3-1 cell line were treated with different concentrations of Aloe emodin and its anti-cancer potential was determined through DNA fragmentation and cell viability assays.