Jiří Zavadil

The paper identifies mutational signatures in cancer genomes caused by tobacco-specific nitrosamines NNN and NNK, showing their unique contribution to specific cancer types.

This paper introduces UDSeq, a duplex sequencing protocol for accurate somatic mutation detection with low DNA input and high coverage, achieving a low error rate and enabling cross-species profiling.

This study examines the mutagenic effects of ethanol and acetaldehyde in rats, finding exposure-specific mutational signatures and suggesting inflammation or oxidative damage as key factors in alcohol-related cancers.

This study investigates the molecular and cellular responses of oral epithelial cells to arsenic and smokeless tobacco exposure using multi-omics analysis and identifies key mechanisms linked to cancer progression.

The paper identifies a unique mutational signature of glycidamide, a metabolite of acrylamide, through experimental and computational analysis, linking it to cancer genome patterns.