B. Yuan

Stromal DUF760-1 and DUF760-2 proteins are degraded by the chloroplast Clp protease system but have very different half-lives

The paper identifies DUF760-1 and DUF760-2 as substrates of the chloroplast CLP protease system, showing they have distinct degradation rates and functional roles.

Wiskott-Aldrich Syndrome Protein Regulates Nucleolar Organization and Function in Innate Immune Response

This study shows that WASP regulates nucleolar structure and function, affecting rRNA transcription and inflammatory cytokine response in macrophages.

A liver-specific mitochondrial carrier that controls gluconeogenesis and energy expenditure

This study identifies SLC25A47 as a liver-specific mitochondrial carrier that regulates gluconeogenesis and energy expenditure by controlling pyruvate flux and FGF21 expression.

Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity

This study shows that mice lacking TG synthesis enzymes in adipose tissue are metabolically healthy and resistant to diet-induced obesity despite reduced TG storage.

Arbidol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo through suppressing ataxia telangiectasia and Rad3-related protein kinase

This study shows Arbidol inhibits esophageal squamous cell carcinoma growth by targeting the ATR kinase and disrupting the DNA replication pathway.

A vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of COVID-19 and related diseases

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

An Aerobic Anoxygenic Phototrophic Bacterium Fixes CO2 via the Calvin-Benson-Bassham Cycle

The paper identifies a novel aerobic anoxygenic phototrophic bacterium, strain B3, capable of photoautotrophy via the Calvin-Benson-Bassham cycle using sulfite or H2 as electron donors.

Time-restricted feeding near dawn entrains long-term behavioral changes through the suprachiasmatic nucleus

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.

The RNA-binding protein HuR promotes nonalcoholic steatohepatitis (NASH) progression by enhancing death signaling pathway

This study shows HuR promotes NASH by enhancing DR5/caspase8/caspase3-mediated hepatocyte death through stabilizing DR5 mRNA.

Structural basis of SARS-CoV-2 polymerase inhibition by Favipiravir

This paper determines the cryo-EM structure of Favipiravir bound to SARS-CoV-2 polymerase, revealing its base-pairing mechanism and implications for antiviral drug development.

Indole acetic acid and lipopeptide-producing endophytic bacteria from Taxus chinesis: toxicity evaluation of metabolic products

The paper screens endophytic bacteria from Taxus chinensis for IAA and lipopeptide production, identifies non-toxic strains, and suggests their potential for biofertilizer use.

Structural and biochemical characterization of nsp12-nsp7-nsp8 core polymerase complex from COVID-19 virus

The paper determines the near-atomic structure of the SARS-CoV-2 polymerase complex and shows reduced activity and thermostability compared to SARS-CoV.