Chemogenetic Hydrogen Sulfide Rescues Vascular Senescence in Ageing
Khatereh Shabanian, Taraneh Shabanian, Lorenzo Da DaltiD, Manuel ColucciiD, Emrah EroğluiD, Héctor Rodríguez Cetina BieferiD, Omer DzemaliiD, Matthias HermanniD, Andrea AlimontiiD, Giuseppe Danilo NorataiD, Francesco PaneniiD, Frank RuschitzkaiD, Seyed Soheil Saeedi SaraviiD
Abstract
Vascular senescence is a central driver of whole-body ageing, yet rescue strategies remain limited. Here we show that hydrogen sulfide (H2S) bioavailability declines in ageing and atherosclerosis and is associated with endothelial senescence. Developing a novel remote-control, endothelial-specific, mitochondria-targeted chemogenetic system, we spatiotemporally controlled H2S generation and thereby mitigated endothelial senescence-driven programs and reversed vascular remodeling in aged mice.
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