Yi Zhang

The transcription factor THAP11 is a general regulator of early embryonic polarization

This study identifies THAP11 as a general regulator of early embryonic polarization across three developmental stages in mice, showing its role in cell fate and morphogenesis.

Hierarchical chromatin polyvalency governs robust gene regulation and organogenesis

The paper shows that H2Aub, not H3K27me3, is the main repressor in chromatin polyvalency, and its disruption causes organogenesis defects in mouse embryos.

Rescue schizophrenia-related phenotypes caused by Setd1a deficiency by histone demethylase inhibitors

This study identifies TAK-418 as a histone demethylase inhibitor that rescues schizophrenia-like phenotypes in Setd1a-deficient mice by restoring H3K4me3 levels and gene expression.

Subcellularly Resolved 3D Translatome in Mouse Oocytes and Early Embryos

The paper profiles the subcellularly resolved 3D translatome in mouse oocytes and early embryos, revealing spatially controlled translation patterns and embryo asymmetry.

NFYA regulates spermatogenesis through multifaceted chromatin interactions

This study uses a novel in vivo protein-degradation approach to show NFYA is essential for spermatogenesis by regulating stage-specific transcriptional programs through chromatin interactions.

Spatially resolved cellular and circuit architecture of the insular cortex controlling different dimensions of pain

The paper maps the spatial organization and functional circuits of the insular cortex involved in different pain dimensions using MERFISH and functional analyses.

Decoding stage-specific functions of PRC2 uncovers a cell-autonomous role in preimplantation development and a non-cell-autonomous role in primordial germ cell fate

This study reveals stage-specific PRC2 functions in preimplantation development and PGC fate through epigenetic dynamics and intercellular communication.

Activating an Interleukin-4-FLT3-STAT6 axis in Multipotent Progenitors Restores Lymphopoiesis in Inflammation and Aging

This study identifies IL-4 as a signal that restores lymphopoiesis in inflammation and aging by activating the FLT3-STAT6 pathway in multipotent progenitors.

NFYA regulates two sequential genome-wide transcriptional activation events during oocyte-to-embryo transition

This study identifies NFYA as a regulator of two sequential transcriptional activation events during oocyte-to-embryo transition, showing its role in primordial follicle activation and zygotic genome activation.

A molecularly defined basalo-prefrontal-thalamic circuit regulates sensory and affective dimensions of pain in male mice

This study identifies a circuit involving mPFC Foxp2+ neurons that modulates sensory and affective pain in male mice, with therapeutic implications for chronic pain.

Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice

This study shows that reducing dysfunctional CD150high HSCs in old mice alleviates aging phenotypes and extends lifespan.

The transcription factor GABPA is a master regulator of naive pluripotency

This study identifies GABPA as a master regulator of naive pluripotency by showing its role in EPI specification and regulation of 47% of EPI genes during the E3.5 to E4.5 transition.

A molecularly defined NAcSh D1 subtype controls feeding and energy homeostasis

The paper identifies a specific NAcSh D1 subtype that regulates feeding and energy homeostasis through molecular and circuit-level mechanisms.

Understanding prefrontal cortex functions by decoding its molecular, cellular and circuit organization

This study maps the molecular, cellular, and circuit organization of the prefrontal cortex and identifies a cell type involved in chronic pain pathogenesis.

Accurate inference of genome-wide spatial expression with iSpatial

iSpatial integrates spatial transcriptomic and scRNA-seq data to infer genome-wide spatial gene expression patterns with higher accuracy and reduced false signals.

Impaired KDM2B-mediated PRC1 recruitment to chromatin causes neural stem cell senescence and ASD/ID-like behavioral deficits

This study shows that KDM2B dysfunction leads to neural stem cell senescence and ASD/ID-like behaviors in mice, linking 12q24.31 microdeletions to neurodevelopmental disorders.

DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and preimplantation development

The paper shows that DPPA2 and DPPA4 are not required for zygotic genome activation or preimplantation development in mouse embryos, contrasting their role in ESCs.

Decoding molecular and cellular heterogeneity of nucleus accumbens with high-throughput scRNA-seq and MERFISH

This study uses scRNA-seq and MERFISH to reveal the molecular and spatial heterogeneity of mouse nucleus accumbens cells and their functional implications.

Tn5 transposase-based epigenomic profiling methods are prone to open chromatin bias

This paper shows that Tn5 transposase-based epigenomic methods introduce open chromatin bias, leading to false positives and misinterpretation of results.