Frank Ruschitzka

This study shows that increasing hydrogen sulfide in aged mice reduces vascular senescence and reverses vascular remodeling.

This study identifies phenylacetate (PAA), a gut microbiota metabolite, as a driver of vascular niche senescence and atherosclerosis in mice through IL-6-Notch1 signaling.

This study shows that SETD2 promotes lipotoxic injury in cHFpEF by regulating SREBP1 and lipid metabolism, and its inhibition improves cardiac function.

This study identifies AQP1 as a regulator of endothelial cell senescence and angiogenesis, showing its dual role in proliferating and senescent cells through modulation of the HDAC4-Mef2A pathway.