Journal of General VirologyGenetic & Genomic MedicinePeer-reviewed journal article
Mutational landscape and dominant lineages in the SARS-CoV-2 infections in the state of Telangana, India
Asmita GuptaiD, Radhakrishnan SabarinathaniD, Pratyusha BalaiD, Vinay Donipadi, Divya Vashisht, Madhumohan Rao KatikaiD, Manohar Kandakatla, Debashis MitraiD, Ashwin Bhikaji DalaliD, Murali Dharan BashyamiD
Abstract
The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing COVID-19 has rapidly turned into a pandemic, infecting millions and causing ~7 million deaths across the globe. In addition to studying the mode of transmission and evasion of host immune system, analysing the viral mutational landscape constitutes an area under active research. The latter is expected to impart knowledge on the emergence of different clades, subclades, viral protein functions and protein-protein and protein-RNA interactions during replication/transcription cycle of virus and response to host immune checkpoints. In this study we have attempted to bring forth the viral genomic variants defining the major clade(s) as identified from samples collected from the state of Telangana, India.
- organism: virus
- assay: whole-genome sequencing
- research focus: phylogenetics / evolution
- approach: statistical model
- Citations
- 22
- FWCI
- 1.74
- Field percentile
- top 13%
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