bioRxivMicrobiologyPreprint
Antiviral activity of Pacific oyster (Crassostrea gigas) hemolymph against a human coronavirus.
Abstract
Coronaviruses can cause severe respiratory infections in humans. In this study we assessed the antiviral activity of Pacific oyster (Crassostrea gigas) hemolymph against a human coronavirus, HCoV-229E. An eight-fold reduction in infectivity of HCoV-229E on Huh-7 cells was observed in the presence of 10% C. gigas hemolymph. Antiviral activity of C. gigas hemolymph positively correlated with its concentration and appears to be active during an intracellular stage of HCoV-229E infection.
- organism: non-human primate
- research focus: host-pathogen & immune response
- approach: experimental assay
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