Journal of Neural EngineeringNeurosciencePeer-reviewed journal article
Fascicles Split or Merge Every ~560 Microns Within the Human Cervical Vagus Nerve
Aniruddha R. UpadhyeiD, Chaitanya KolluruiD, Lindsey N. DruscheliD, Luna Al LababidiiD, Sami S. AhmadiD, Dhariyat M. MenendeziD, Ozge N. BuyukcelikiD, Megan L. SettelliD, Stephan L. BlanziD, Michael W. JenkinsiD, David L. WilsoniD, Jing ZhangiD, Curtis M. TatsuokaiD, Warren M. GrilliD, Nicole A. PelotiD, Kip A. LudwigiD, Kenneth J. GustafsoniD, Andrew J. ShoffstalliD
Abstract
1Vagus nerve stimulation (VNS) is FDA approved for stroke rehabilitation, epilepsy, and depression; however, the vagus functional anatomy underlying the implant is poorly understood. We used microCT to quantify fascicular structure and neuroanatomy within human cervical vagus nerves. Fascicles split or merged every ~560 m (17.8 {+/-} 6.1 events/cm). The high degree of fascicular splitting and merging in humans may explain the clinical heterogeneity in patient responses.
- Citations
- 45
- FWCI
- 3.25
- Field percentile
- top 6%
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Prevalence of sympathetic fibers within the rat cervical vagus, and functional consequence on physiological effects mediated by vagus nerve stimulation (VNS).
Ashlesha Deshmukh, Rex Chin-Hao Chen, … Kip A. Ludwig·Journal of Neural EngineeringPeer-reviewed·Mar 16, 2026
- Organotopic organization of the cervical vagus nerve
Nicole Thompson, Enrico Ravagli, … David S. Holder·bioRxiv·Feb 24, 2022
- Organ- and function-specific anatomical organization of the vagus nerve supports fascicular vagus nerve stimulation
Naveen Jayaprakash, Weiguo Song, … Stavros P. Zanos·bioRxiv·Mar 7, 2022
- Vagus nerve stimulation using an endovascular electrode array
Evan N. Nicolai, Jorge Arturo Larco, … Gregory A. Worrell·Journal of Neural EngineeringPeer-reviewed·Jun 5, 2023
- Human vagus nerve fascicular anatomy: a microCT segmentation and histological study
Nicole Thompson, Svetlana Mastitskaya, … David S. Holder·bioRxiv·Jul 4, 2023
- Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect
S. L. Blanz, E. D. Musselman, … K. A. Ludwig·bioRxiv·May 19, 2022