Svetlana Mastitskaya

Relaxation of cardiac pericytes by GLP-1 activating KATP channels mediates remote ischaemic preconditioning cardioprotection

This study shows that remote ischaemic preconditioning protects the heart by releasing GLP-1, which relaxes cardiac pericytes and reduces no-reflow.

Anatomical and functional organization of cardiac fibers in the porcine cervical vagus nerve allows spatially selective efferent neuromodulation

This paper demonstrates spatially-selective vagus nerve stimulation (sVNS) can target cardiac efferent fibers to decrease heart rate without stimulating afferent-related reflexes, improving precision and efficacy of neuromodulation for cardiac disease.

Human vagus nerve fascicular anatomy: a microCT segmentation and histological study

This study uses microCT and histology to analyze the fascicular organization of human vagus nerves, revealing differences between left and right nerves and potential for targeted neuromodulation.

Organotopic organization of the cervical vagus nerve

The paper identifies localized fascicles in the porcine cervical vagus nerve that correspond to specific organ functions, supporting the concept of organotopy and enabling targeted neuromodulation.

MicroCT optimisation for imaging fascicular anatomy in peripheral nerves

The paper optimizes microCT protocols to segment and track fascicles in rat sciatic and pig vagus nerves, aiming to improve VNS targeting and reduce off-target effects.

Astrocytes modulate baroreceptor reflex sensitivity at the level of the nucleus of the solitary tract

This study shows that astrocytes in the nucleus of the solitary tract modulate baroreflex sensitivity through calcium signaling and ATP release, influenced by 5-HT and glutamate.