David S. Holder

This paper develops a wireless battery-free implantable device for selective vagus nerve stimulation, demonstrating reduced off-target effects in pigs and a human trial.

This paper demonstrates spatially-selective vagus nerve stimulation (sVNS) can target cardiac efferent fibers to decrease heart rate without stimulating afferent-related reflexes, improving precision and efficacy of neuromodulation for cardiac disease.

This study uses microCT and histology to analyze the fascicular organization of human vagus nerves, revealing differences between left and right nerves and potential for targeted neuromodulation.

The paper identifies localized fascicles in the porcine cervical vagus nerve that correspond to specific organ functions, supporting the concept of organotopy and enabling targeted neuromodulation.

The paper optimizes microCT protocols to segment and track fascicles in rat sciatic and pig vagus nerves, aiming to improve VNS targeting and reduce off-target effects.