Andrew J. Shoffstall

Mapping the Fascicular Morphology and Organization of the Human Sciatic Nerve via High-Resolution MicroCT Imaging

This paper uses high-resolution microCT imaging to map fascicular organization in the human sciatic nerve, revealing asymmetry in branch lengths and fascicle distribution, which informs neuroprosthetic design.

Identification of low threshold off-target activation pathways during stimulation of carotid baroreceptor afferents in swine.

This study identifies off-target neural pathways activated during carotid baroreceptor stimulation in swine, contributing to side-effects of baroreflex activation therapy.

Prevalence of sympathetic fibers within the rat cervical vagus, and functional consequence on physiological effects mediated by vagus nerve stimulation (VNS).

This study shows that sympathetic fibers are present in the rat cervical vagus nerve and that stimulating the vagus nerve can activate these fibers, leading to tachycardia rather than bradycardia.

Impact of infusion conditions and anesthesia on CSF tracer dynamics in mouse brain

This study examines how infusion location, rate, and anesthesia affect CSF tracer dynamics in mice using Gd-DTPA and MRI.

Automated 3D Segmentation of Human Vagus Nerve Fascicles and Epineurium from Micro-Computed Tomography Images Using Anatomy-Aware Neural Networks

This paper introduces a 3D U-Net with an anatomy-aware loss function for automated segmentation of human vagus nerve fascicles and epineurium from microCT images, achieving high accuracy and reducing anatomical errors.

Micro-CT Analysis of a Needle to Nerve Approach for Interfascicular Peripheral Nerve Stimulation in Porcine Nerves

This paper quantifies interfascicular electrode placement in porcine nerves using micro-CT and histology, showing 84% of placements were interfascicular and demonstrating the potential of MiiNS as a selective peripheral nerve interface.

Epidural Spinal Cord Recordings (ESRs): Sources of Artifact in Stimulation Evoked Compound Action Potentials

This study identifies and characterizes sources of artifact contaminating evoked compound action potentials (ECAPs) in epidural spinal cord recordings, highlighting challenges in distinguishing neural signals from artifacts in a swine model.

Fascicles Split or Merge Every ~560 Microns Within the Human Cervical Vagus Nerve

The paper quantifies fascicular splitting and merging in human cervical vagus nerves, finding events occur every ~560 microns and may explain clinical response variability.

In vivo visualization of pig vagus nerve 'vagotopy' using ultrasound

This paper demonstrates the use of intraoperative ultrasound to visualize pig vagus nerve fascicular organization (vagotopy) and improve cuff placement for vagus nerve stimulation.

Sources of Off-Target Effects of Vagus Nerve Stimulation Using the Helical Clinical Lead in Domestic Pigs

The paper identifies specific neuroanatomical pathways causing off-target effects of vagus nerve stimulation in pigs and characterizes dose-response curves for on- and off-target effects.

Functional Vagotopy in the Cervical Vagus Nerve of the Domestic Pig: Implications for the Study of Vagus Nerve Stimulation

The paper characterizes the anatomy of the cervical vagus nerve in domestic pigs, identifying structural features relevant to vagus nerve stimulation and comparing them across species.