bioRxivCancer Biology
Integrative Analysis the characterization of peroxiredoxins in pan-cancer
L. Gao, J. Meng, C. Yue, X. Wu, Q. Su, H. Wu, Z. Zhang, Q. Yu, S. Gao, S. Fan, L. Zuo
Abstract
Peroxiredoxins (PRDXs) are antioxidant enzymes protein family members that involves the process of several biological functions, such as differentiation, cell growth. Considerable evidence demonstrates that PRDXs play critical roles in the occurrence and development of carcinomas. However, a systematic analysis of PRDXs in cancers is deficiency. Therefore, we perform a comprehensive analysis of PRDXs in 33 cancer types including mRNA expression profiles, genetic alterations, methylation, prognostic values, potential biological pathways and target drugs. Moreover, we validated that PRDX6 could regulate cancer cell proliferation via JAK2-STAT3 pathway and involve into the process of cell cycle in bladder cancer.
- organism: human
- assay: bulk RNA-seq
- assay: DNA methylation
- research focus: differential expression
- research focus: gene regulatory network inference
- research focus: drug response / drug discovery
- approach: statistical model
- approach: machine learning (classical)
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