Type IV pilus length determines virulence by regulating a hidden subpopulation of non-contributing filaments
Zil K. Modi, Jessie L. ReediD, Ahmed O. YusufiD, Tyler Payne, Neel Chalemela, Sam Denison, Matthias D. KochiD
Abstract
Many clinically important bacterial pathogens, including Pseudomonas, Vibrio, Neisseria, and Acinetobacter species, employ dynamic extracellular appendages called type IV pili (T4P) to facilitate virulence through cyclical extension and retraction of pilus filaments. To dissect how T4P dynamics govern pathogenesis, we engineered a genetic system to precisely tune pilus length across a continuum. We demonstrate that pilus length critically determines four major T4P-dependent virulence traits in Pseudomonas aeruginosa (motility, surface sensing, biofilm formation, and phage infection) and reveal a hidden subpopulation of pili that are unable to interact with environmental substrates or host cells, rendering them non-contributing to any T4P-mediated function. Integrating molecular dynamics simulations, we show that low inner-membrane abundance of the major pilin forces the extension mechanism into transient idle states, restricting both velocity and final length. Molecularly, this finding reveals how two key biophysical parameters, pilin abundance and diffusion, impose a fundamental physical constraint on T4P assembly, and that regulating pilin abundance presents a strong lever over regulating pilus count for controlling the amount of functionally contributing filaments. Contrary to the prevailing view that retraction force generation primarily dictates T4P-mediated behaviors, our results establish extension dynamics as the overlooked bottleneck constraining all retraction-enabled virulence traits, with population heterogeneity in length enabling adaptive bet-hedging.
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