Ankur B. Dalia

This study identifies two D-loop resolution systems in bacteria, YraN/ComM and CoiA/RadA, that work together to process the transformation D-loop during natural genetic transformation.

This study shows temperate phages in V. cholerae biofilms can displace non-lysogenized bacteria but face spatial and immunity constraints that limit their competitive advantage.

This study shows that low DNA-binding affinity of TfoS promotes its dependence on ChiS for activating PtfoR, which is necessary for optimal Vibrio cholerae fitness on chitin.

The paper models and validates the coordination mechanism between PilT and PilU ATPases during type IV pilus retraction using AlphaFold 3 and molecular dynamics simulations.

This study shows that the ratio of minor-to-major pilins regulates the dynamic activity of T4aP in Vibrio cholerae.

This study identifies the regulatory mechanisms of nitrogenase in Vibrio natriegens, showing that NtrBC is not essential but important for timely expression, while NifA autoactivation suffices for nitrogenase gene expression.

This study compares mutation accumulation in bacterial monocultures and cocultures, finding that cross-feeding can limit rather than promote metabolic dependencies.

The paper uses structural modeling and experimental analysis to reveal how CBP and ChiS regulate chitin utilization in Vibrio cholerae through an allosteric switch mechanism.

The paper presents a 3.3 Å cryo-EM map of Vibrio cholerae competence pilus and a full-length pseudoatomic model of the CPM, revealing unique structural features and mechanical properties.

This study identifies a protein-protein interaction between ComM and DprA that is critical for DprA to recruit ComM to promote recombination during natural transformation in Gram-negative bacteria.

This paper shows that ChiS and TfoS, two transmembrane transcriptional regulators in V. cholerae, work together to activate natural transformation in response to chitin by recruiting the PtfoR promoter to the membrane and facilitating TfoS interaction.

This study identifies distinct molecular mechanisms for DNA-binding by competence T4P in Gram-positive and Gram-negative bacteria using Streptococcus pneumoniae as a model.

This study shows SbcB promotes natural transformation in Vibrio cholerae without relying on its exonuclease activity, by interacting with RecA during homologous recombination.

The paper introduces MuGENT, a method for high-efficiency multiplex genome editing in Vibrio natriegens using natural transformation.