bioRxivCancer BiologyPreprint
Global profiling of the crotonylome in Small Cell Lung Cancer
Abstract
Small cell lung cancer is a deadly neuroendocrine lung cancer subtype, which harbors the driver mutations of RB1 and TP53 as well as EP300/CREBBP. Since CREBBP/p300 are two prominent crotonyl-CoA transferases responsible for the global crotonylation in cells, here we investigated the crotonylome in SCLC tissues compared with normal lung tissues through TMT labeling coupled with LC-MS/MS and found unique patterns of protein crotonylation in SCLC related pathways.Competing Interest StatementThe authors have declared no competing interest.View Full Text
- organism: human
- assay: proteomics
- research focus: protein folding & dynamics
- approach: experimental assay
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