Author

Loukia Georgiou Karacosta

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-1491-4773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:trajectory inference· 2

Frequent Co-Authors

Alejandra G. SerranoiD· 3 shared Bingnan ZhangiD· 3 shared Carl Michael GayiD· 3 shared Catherine Allison StewartiD· 3 shared Lauren A. ByersiD· 3 shared Mukulika BoseiD· 3 shared Alexa Halliday· 2 shared Benedict AnchangiD· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

Alejandra G. SerranoORCID

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Author profile →

4 papers

Recent·Most cited

DLL3 expression predicts response and long-term outcome in small cell lung cancer patients treated with tarlatamab

Bingnan Zhang, Lingzhi Hong, Kaiwen Wang, Catherine Allison Stewart, Komal Shah, Wei-lien Wang, Alejandra Serrano, Luisa Maren Solis Soto, Robert J. Cardnell, Alexa Halliday, Mitchell Parma, Elyse R. Lopez, Mukulika Bose, Cole Ruoff, Shafqat Ehsan, , Lauren A. Byers

This study shows DLL3 expression level predicts response and long-term survival in SCLC patients treated with tarlatamab.

bioRxiv · Sep 7, 2026 · PreprintCancer Biology

YAP1 defines an emergent, plastic population of relapsed small cell lung cancer

Catherine Allison Stewart, Kavya Ramkumar, Runsheng Wang, Yuanxin Xi, Alexa Halliday, Lixia Diao, Qi Wang, Alejandra G. Serrano, Sarah Groves, Simon Heeke, Azusa Tanimoto, Laura Kaiser, Yan Yang, Whitney E. Lewis, Jody V. Vykoukal, , Carl Michael Gay

This study identifies YAP1-positive cells in relapsed SCLC that exhibit drug tolerance and transition from SCLC to LCNEC-like features, losing some targets but gaining others.

Journal of Thoracic Oncology · Apr 20, 2026Peer-reviewedCancer Biology

CyTOF-based profiling of circulating tumor cells predicts aggressiveness and therapy response in SCLC liquid biopsies at a personalized level

Mukulika Bose, Cole Ruoff, Shafqat Ehsan, Catherine Allison Stewart, Alberto José da Silva Duarte, Sayantan Bhattacharyya, Jiaqi Li, Benedict Anchang, Thomas Welte, Ashley Victorian, Fabiola Ester Lujan, Lixia Diao, Jing Wang, Ken Chen, Bingnan Zhang, , Loukia Georgiou Karacosta

This study uses CyTOF to profile circulating tumor cells in SCLC patients, identifying subtype-specific markers and treatment response correlations.

bioRxiv · Dec 19, 2025 · PreprintCancer Biology

Mapping Lung Cancer Epithelial-Mesenchymal Transition States and Trajectories with Single-Cell Resolution

Loukia Georgiou Karacosta, Benedict Anchang, Nikolaos Ignatiadis, Samuel C. Kimmey, Jalen Anthony Benson, Joseph B. Shrager, Robert John Tibshirani, Sean C. Bendall, Sylvia K. Plevritis

The paper maps EMT and MET states in lung cancer using single-cell resolution and a novel computational tool, showing differences in trajectories and providing a framework for clinical sample characterization.

Nature Communications · Dec 6, 2019Peer-reviewedSystems Biology