FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS
H. Chen, E. E. Gardner, Y. Shah, K. Zhang, A. Thakur, C. Zhang, O. Elemento, H. Varmus
This study shows that overproducing cMYC in TP53 and RB1-depleted hESC-derived PNECs leads to aggressive SCLC-like tumors with metastatic properties and NEUROD1 expression.
bioRxiv · Oct 6, 2023 · PreprintCancer Biology