Author

S. K. Alam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

L. H. Hoeppner· 4 shared L. Wang· 3 shared A. C. Roden· 2 shared C. E. Hernandez· 2 shared Z. Zhu· 2 shared A. M. Coyle· 1 shared A. S. Mansfield· 1 shared D. K. Hoffman· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

L. H. Hoeppner

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

IKKα promotes lung adenocarcinoma growth through activation of ERK signaling via DARPP-32-mediated inhibition of PP1 activity

S. K. Alam, L. Wang, Z. Zhu, L. H. Hoeppner

bioRxiv · Jul 8, 2022 · PreprintCancer Biology

DARPP-32 promotes ERBB3-mediated resistance to molecular targeted therapy in EGFR-mutated lung adenocarcinoma

S. K. Alam, Y. Zhang, L. Wang, Z. Zhu, C. E. Hernandez, Y. Zhou, N. Yang, J. Lei, X. Chen, L. Zeng, M. A. Klein, L. H. Hoeppner

This study identifies DARPP-32 as a mediator of ERBB3-driven resistance to EGFR TKIs in lung adenocarcinoma, showing its role in promoting oncogenic signaling and tumor progression.

bioRxiv · Feb 12, 2021Cancer Biology

ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumor cell survival

S. K. Alam, L. Wang, Y. Ren, C. E. Hernandez, F. Kosari, A. C. Roden, R. Yang, L. H. Hoeppner

The paper shows that ASCL1-regulated DARPP-32 and t-DARPP promote SCLC growth and survival through Akt/Erk signaling and anti-apoptotic pathways, with t-DARPP overexpression linked to Notch signaling activation in SCLC patients.

bioRxiv · Jul 16, 2019Cancer Biology

DARPP-32 and t-DARPP promote lung cancer growth through IKKα-dependent cell migration and Akt/Erk-mediated cell survival

S. K. Alam, M. Astone, P. Liu, S. R. Hall, A. M. Coyle, E. N. Dankert, D. K. Hoffman, W. Zhang, R. Kuang, A. C. Roden, A. S. Mansfield, L. H. Hoeppner

The paper shows that DARPP-32 and t-DARPP promote lung cancer growth via IKKα-dependent migration and Akt/Erk-mediated survival, with t-DARPP linked to poor survival and higher tumor stages.

bioRxiv · Dec 6, 2017Cancer Biology