In vivo Protective Efficacy of Emodin in Swiss Albino Mice Induced with Dalton Ascitic Lymphoma

Abstract

Lymphoma is a tumor that affects lymphoid tissues in the body. Treating lymphoma has become challenging because of the complexity of disease pathology, drug resistance mechanisms and side effects of existing chemo and radiation therapies. Treating cancers/tumors with plant based natural compounds is gaining interest recently because of their less toxicity profiles and efficiency in controlling the disease severity. Emodin is one such compound with such anti-cancer/tumor properties. It has immunosuppressive and anti-cancer properties through multiple ways. In this study, we have studied the therapeutic effect of emodin molecule in the DAL induced lymphoma, a well-established murine model to study and test the anti-lymphoma drugs. Our data has shown an outstanding therapeutic effect of emodin in controlling the lymphoma readouts in DAL induce Swiss Albino mice. These effects were studied in comparison with a standard drug molecule called methotrexate. Furthermore, the in-silico analysis has shown that emodin as a potential drug candidate for lymphoma based on the Lipinskis rule of 5.