C. Vincent-Fabert

REL deregulation stands as a primary hit for AID-imprinted B-cells along the germinal center competition

This study shows REL deregulation gives AID-imprinted B-cells a competitive advantage in germinal centers, promoting expansion and potential transformation into aggressive lymphomas.

B-cell specific expression of the murine Myd88L252P mutation correlates with the establishment of an immunosuppressive microenvironnement in Waldenstrom macroglobulinemia lymphoplasmacytic lymphoma

This study shows that B-cell specific Myd88L252P mutation in mice leads to an immunosuppressive microenvironment in Waldenstrom macroglobulinemia, promoting T-cell exhaustion and disease progression.

B-cell enforced expression of the mouse ortholog of MYD88L265P is responsible for Waldenstrom-like B-cell lymphoma.

This study shows that enforced expression of MYD88L252P in B-cells leads to a lymphoplasmocytic B-cell lymphoma with a serum IgM peak in mice.

Pre-Clinical Blocking of PD-L1 molecule, which expression is down regulated by NF-κB, JAK1/JAK2 and BTK inhibitors, induces regression of activated B-cell lymphoma.

The paper shows that blocking PD-L1 in a mouse model of activated B-cell lymphoma leads to tumor regression, suggesting potential for PD-1/PD-L1 axis therapies combined with tyrosine kinase inhibitors.

Reproducing Transformation of Indolent B-cell Lymphoma by T-cell Immunosuppression of L.CD40 Mice.

The paper shows that T-cell immunosuppression in L.CD40 mice transforms indolent B-cell lymphoma into an aggressive form, highlighting immune surveillance's role in disease progression.