Behavior GeneticsGenetic & Genomic MedicinePeer-reviewed journal article
The CADM2 gene and behavior: A phenome-wide scan in UK-Biobank
Joëlle A. PasmaniD, Zeli CheniD, Dirk J. A. SmitiD, Jacqueline M. VinkiD, Michel C. van den OeveriD, Tommy PattijiD, Taco J. De VriesiD, Abdel AbdellaouiiD, Karin J. H. VerweijiD
Abstract
This phenome-wide association study examined SNP and gene-based associations of the CADM2 gene with 242 psycho-behavioral traits (N=12,211-453,349). We found significant associations with 51 traits, many more than for other genes. We replicated previously reported associations with substance use, risk-taking, and health behavior, and uncovered novel associations with sleep and dietary traits. Accordingly, CADM2 is involved in many psycho-behavioral traits, suggesting a common denominator in their biology.
- organism: human
- assay: GWAS summary statistics
- research focus: GWAS / association mapping
- approach: statistical model
- Citations
- 33
- FWCI
- 4.07
- Field percentile
- top 5%
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